Chair of Biotechnology, Bioengineering and Biochemistry was formed on 06. 21. 2014 by merging of two smaller Chairs of Biotechnology and Biochemistry (Order №01/281). It is headed by the dean of the department of Biotechnology and Biology Victor V. Revin, Doctor of Biological Sciences, professor and an honored science worker of Russian Federation.

Victor V. Revin- Doctor of Biological Sciences, professor, head of the Chair of Biotechnology, Bioengineering and Biochemistry

Academic staff of the Chair of Biotechnology, Bioengineering and Biochemistry

The Chair of Biotechnology, Bioengineering and Biochemistry has a long history. Originally, it was the Chair of Biology that was formed in 1965 and was a part of the department of Chemistry and Biology of Mordovian State University. It was founded and headed by Ekaterina V. Sapozhnikova-Doctor of Biological Sciences, professor and later an honored science worker of MASSR. Among the first members of academic staff were senior professor L. S. Dorofeeva (studied at St. Petersburg State Technical Institute and worked as a technologist at Romodanovo’s sulfitation factory) and G. S. Barnashova (after graduating from the Teachers Institute of Mordovia after A. I. Polezhaev in 1953 worked as teacher in school, and since 1957 as a laboratory assistant at the Chair of Chemistry). The newly-formed Chair was also joined by a junior research associate V. P. Tishenko, laboratory worker R. A. Kirlyanova, G. N. Savchenko and a group of post-graduate students-N. B. Alba, L. N. Matveeva, S. M. Zhivechkov and others. 

E. V. Sapozhnikova created a research team that quickly began to work on researching the pectic substances and pectolytic enzymes of fruit crops, leaf crops and wild plants. This work had a great impact on improving the national economy of MASSR that needed scientific recommendations to hasten the ripening of fruit and vegetables, to modify the technologies of storage and processing of end product.

The Chair has had scientific cooperation with A.N.Bach Institute of Biochemistry, Lomonosov Moscow State University, Lobachevsky University (Nizhny Novgorod), Academy of Sciences of Moldova, Baku’s Research Institute of orcharding, viticulture and subtropical cultures. The Chair has also created conditions for development of a completely new specialization.

L. S. Dorofeeva began giving lectures on Biotechnology, she was succeeded by A. A. Kotov who had previously worked at «Biohimic»; R. E. Kiseleva and L. S. Dorofeeva gave lectures on Biochemistry of meat and milk; N. V. Alba gave lectures on BAS and Technology of processing agriproduct; G. S. Barnashova gave lectures on Enzymology. That gradually led to a development of a completely new speciality-Biotechnology.

In 1987 two sub-divisions (Interdepartmental lab of Biophysics and a Lab of Industrial Microbiology) were merged to form the Chair of Biotechnology. The President of the University professor A. I. Suharev actively assisted the organization of the new Chair. Doctor of Science A. I. Kotov was the first Chairman of the Chair and had had a vast experience of managerial and practical work at enterprises of microbiological industry.

By that time the Chair had been conducting researches within 3 major fields of study: studying of biodeteriorations of materials and products caused by microorganisms (inquiry made by the Ministry of Defence, supervised by A. I. Kotov); searching for natural producers of beta-lactamase and testing of their stability and variability (inquiry made by the Factory of Pharmaceutical drugs of Saransk, supervised by T. N. Pritkova); lipidic’s fase impact on the functioning of ion-transportational systems of biological membranes (inquiry made by the State committee for science and technology, supervised by V. V. Revin).

After V.V. Revin was elected for the position of the Chairman of the sub-division of Biotechology in 1992 new researches were promptly launched as well as material and methodical bases were extended to support the newly opened speciality of Biotechnology. Despite the short span of time, the sub-division of Biotechology formed a major scientific and technical potential thanks to the professional academic staff. The Chair’s scientific and technical achievements are an excellent evidence of that.

New and modern methods of research have constantly been implemented, such as: cultivation of objects in fermenters with program guidance, microscopy with a system of digital visualization and a system of computer analysis, methods of analytical control by using of the modern chronographic and electrophoretic equipment with computer data processing.

The Chair has created a base for international scientific conferences that gather outstanding specialists from Russia, Belarus, Canada, Lithuania and Romania as well as regional scientific conferences for young scientists. 

Since the creation of the Chair more than 1000 of engineers-biotechnologists have graduated. Here are some of the activities they are involved in after the graduation: production and technology (engineer, technologist in food industry, pharmaceutical industry, microbiological industry), design and construction (engineer), research (junior research associate), organization and management.

The graduates if the Chair work at cheese factory «Ichalkovsky», cheese factory «Sarmich», «Mordovspirt», «Hlebozavod», Saransk Brewing company, «Biohimik», milk factory «Saransky», «Biosintez», «Mordovia-Holod», «Talina» and many other processing companies of Mordovia and Russia as well as at leading scientific centres of Russia, Europe and the USA. 

In 2006 the Chair created a base for opening of a Biotechnological centre which consists of 2 scientific and academic facilities-«Nanobiotechology» and «DNA-diagnostics and genome research».

The Chair has established several different labs-the Lab of Fundamental Biotechnology, the Lab of Microbal Glycans, the Lab of Biocomposite Materials, the Lab of Fermentative Biotechnologies, the Lab of Biopreparations and the Lab of Biophysics.

Also, the Chair created a Society of a regional office of Russian society of biotechologists and a regional office of MOIP. The year of 2005 marked the opening of the leading scientific school-«Biotechnology and Bioenergetics».

Today the academic staff of the Chair of Biotechnology, Bioengineering and Biochemistry consists of 19 specialists, among them are 3 Doctors of Science and 12 scientific assistants.

The Chair carries out researches of «Energy efficiency and New materials» that are the part of the priority branch №1 of the University’s development. The central area of scientific focus of the Chair includes biotechnology of composite materials; biotechnology of biological products for agricultular industry; biotechnology of bioethanol obtained from nanostructured materials; biodestruction of xenobiotics in the environment; technology of provision of general health; biotechnology of microbic glycans; obtaining of feed and probiotic preparations; physical, chemical and molecular means of apoptosis; studying of molecular and cellular excitation mechanisms, degeneration and regeneration of excitable formations; studying of the mechanisms of oxygen-transporting function of erythrocytes.

The technologies of obtaining of ecologically-safe composite materials from the waste products of plant raw material have been successfully developed. The sample of the created products were presented at Russian and Republican scientific exhibitions and were included in the register of the best inventions. Some of the Chair’s products were introduced into production, for example a sour-milk beverage «Zdorovie», soft-ripened cheese «Aibolit» and «Oktyabrsky», sour cream sauce and processed cheese with addition of modifilan. Besides, the Chair focuses its attention on ecology and waste-free technologies and studies biodegradation and neutralization of xenobiotics, sewage and soil treatment, recycling of DDGS.

Members of the Chair have published a vast variety of academic literature: a textbook and a study guide classified by AMA- «Biophysics», «Laboratory practicum in biotechnology», «Introductive course in biotechnology: from test-tubes to bioreactors», «Biotechnology of ethanol», «Biotechnology of bacterial exopolysaccharides, «Laboratory practicum in biophysics, human and animal physiology», «Practicum in human and animal physiology», a monograph «Role of lipids in functioning of excitable biological membranes», «Fundamental and applicative basics of biotechnology of environmental friendly composite materials», «Role of biogenic amines in the processes of disruption of adaptation in cases of lungs pathology» and other study guides and work programs for special courses.

Every year the Chair hosts the Republic conference of the young scientists, Ogarev’s readings in which the students and post-graduate students of the Chair take part, sectional sessions of scientific conference «Science and innovations in Mordovia». The Chair researches have a great area of focus and are aimed on improving the quality of life not only in Mordovia but in the country in whole.

In September, 2015 the-sub department held a nationwide conference «Perspectives of development of chemical and biological technologies in the XXI century», in which specialists from abroad also took part.

The Chair’s publishing activity has been increasing consistently. The Chair’s scientific achievements have been acclaimed nationally and world-wide. This is proved by the number of grants won in recent years: RFBR grants, the Ministry of Education and «Universities of Russia» program grants. The Chair won a contest named «Carrying out of fundamental scientific researches and trial experiments by young scientists» in 2015, and a project on «Studying of the mechanisms of regulations of oxygen-transporting function of erythrocytes’ hemoglobin». At the present time the Chair is carrying our researches for several grants, annual overall worth of which is over 20 million roubles.

To increase the efficiency of staff training and to simplify the cooperative development of new technologies, the Chair signed long-term contracts with leading enterprises of Mordovia- «Mordovspirt», milk factory «Saransky», cheese-making factory «Ichalkovsky», etc. These enterprises have the Chair’s branches functioning which are used to hold special courses and practices for students. 

RESEARCH AREAS OF THE CHAIR OF BIOTECHNOLOGY, BIOENGINEERING AND BIOCHEMISTRY

BIODEGRADABLE MULTIPURPOSE PROTEIN-POLYSACCHARIDE MEMBRANES

The Chair of biotechnology, bioengineering and biochemistry carries out researches to obtain biopolymer protein-polysaccharide membranes linked with transglutaminase. This kind of membranes is homogeneous and their durability and tensility are comparable to those of polyethylene membranes, and they are capable of biodegradation in situ. Besides, they can be used as a substitute for synthetic polymers that are virtually non-degradable in situ. 

Usage of polysaccharides, proteins and ferments of biological origin in composite compound allows to replace petrochemical materials that is now widely used for production of synthetic plastic materials, thus making possible the achievement of not only biodegradation, but also of durability of the membranes produced. Biostability and high ecological compatibility of the membranes is increased when using transglutaminase as one of the linking agents that is biologically active and is capable of proteins’ cross-linking. 

Biodegradable membranes that are obtained that way contain proteins, gelatins or lactoprotein, as well as polysaccharides-alginate, chitosan or BC and have following characteristics: tensility (100-250%), durability (15-40 MPa), soil biodegradation (1-3 months). 

Protein-polysaccharides based membranes and polymers that are linked with transglutaminase can be used in medicine, veterinary medicine, pharmaceutical, alimentary and cosmetic industry. Also, such membranes and polymers can be used in production of food wrap, capsules and packaging material.

Biodegradable protein-polysaccharide membranes linked with ferment 

General arrangement for producing of the membranes

BIOTECHNOLOGY OF BIOETHANOL OBTAINED FROM ULTRADISPERSIVE PLANT RAW MATERIAL 

The Chair is developing the technology of obtaining of burnable and alimentary bioethanol by deep mechano-biochemical processing of ultradispersive plan raw material followed by a leavenous bioconversion. Grain is used in the process of the development of the technology of obtaining of alimentary ethanol, and for burnable ethanol cellulose containing material is used with its particle of about 100-300 microns. 

Morselized raw material undergoes fermentative hydrolysis by a complex of highly active ferments under mild conditions and is then attenuated by yeast. Technologies for attenuating of mesh standard and high density were also developed. Combination of methods of deep mechanical and biochemical processing eliminates one of the classic stages of ethanol production-cooking (when producing alimentary ethanol) or chemical hydrolysis (when producing burnable ethanol). 

Procedure of obtaining of ethanol from jet-milled grain 

Aforementioned technologies allow to reduce power consumption and capital investments while the alcohol output actually grows. All the researchers are carried out in cooperation with JSCo «Mordovspirt». 

Followin patents have been granted: 

1) Method of obtaining of alcohol / V.V. Revin, N.A. Atykyan, D.O. Zakharkin, invention patent RUS 2552165 06.08.2013 

2) Method of obtaining of alcohol from lignocellulosic material / V.V. Revin, N.A. Atykyan, D.O. Zakharkin, invention patent RUS 2558303 07.10.2013 

3) Method of obtaining of alcohol / N.A. Atykyan, V.V. Revin, invention patent RUS 2506312 16.04.2012 

4) Method of obtaining of alcohol / V.V. Revin, N.A. Atykyan, invention patent RUS 2407798 22.04.2009

BIOTECHNOLOGY OF BIOPREPARATIONS FOR AGRICULTURE 

The Chair of biotechnology, bioengineering and biochemistry is carring out researches to optimize the conditions of obtaining of biopreparations based off of bacteria Pseudomonas aureofaciens and Azotobacter Vinelandii to protect plants from blight caused by plant photogenic fungi that suppress the growth of cultivated plants and lead to the yield reducing. 

It is widely known that the usage of chemical fungicides causes mass environment pollution and reduction of soil fertility. That’s exactly why the role of biological protection of plants in maintaining the safety of agricultural products and increasing of beneficial microflora is truly immense. 

Thus far the staff of the Chair has been finishing the work on a process scheme of producing multifunctional biopreparation; its influence on germinative ability of Gramineae, Oleraceus and industrial cultures has been studied as well as lab tests have been carried out to find out the possible increased resistance of plants to phytopathogens and stress conditions. Moreover, the development of the technology of creation of the consortium of microorganisms that has a complex biological effect is in progress. 

BIOTECHNOLOGY OF ADHESIVES OF BIOLOGICAL ORIGIN.

During the last years natural adhesives have found extensive use. This is mostly due to the ecological problems and ways to solve them that are constantly found in highly developed countries. For example, merchandise that is packed in a synthetic glue-containing package is not imported in many European, Asian and American countries. That depends on an increased demand of customers that want any merchandise to be ecologically friendly.

The main component of adhesive is a glue matter that provides adhesional and cohesive durability. Biopolymers such as collagen, casein, amylopectin, dextrin and etc. are a basis of natural adhesives and usually are quite expensive. Microbic polysaccharides and proteins can be a substitute for them and can be obtained from food waste that contains nutritional ingredients that are necessary for this task, for example: molasses, milk whey, butter milk, brewery and alcohol waste. 

Constant search for new and cheaper sources of adhesives is crucial. Waste and recyclable materials from microbiotic fabrication contain a lot of biopolymers. For many years the Chair has studied ways to obtain various adhesives that partly consist of food and pharmaceutical industies’ waste; modification of the main components of adhesives; modification products are also studied i.e. their adhesive capacity, various additives (obtained from different sources of waste material) and their influence on the adhesive capacity of bioadhesives are tested. One of such ways consists in dextran synthesis by using Leuconostoc mesenteroides in cheap nutrient mediums that contain sugar, dairy and alcohol industries’ waste. While microbes grow they form a great amount of highly polymeric compounds such as polysaccharides that have some valuable adhesive features. They can be used as a main component of bioglues and also as an adhesive for ecologically friendly biocomposite materials. Those polysaccharides are completely harmless and are used even in medical practice. This is why glue compounds that have them as a basis can be used in food industry for applying labels and producing of paper containers.

The staff of the Chair has optimized the composition of nutrient mediums containing molasses, butter-milk, milk whey and grain stillage as well as the conditions of fermentation that provide the maximum output of industrial dextran.

Levan is another promising biopolymer and is produced by a wide range of microorganisms, specifically by Azotobacter. This polysaccharide is formed with the residue of fructose (D-fructofuranose connected by β–2 → 6 and by α–2 → 1 connections in branching points) that is packed in compact spherical structures. Unlike the majority of other polysaccharides, levan isn’t water-swellable and is capable of forming crystals. Levan has outstanding adhesion properties due to the large amount of hydroxyl groups that help to form glue bonds with different substrates. It is absolutely harmless for people and ecologically friendly. Bioadhesives based on bacterial polysaccharides can be used to produce corrugated board or to obtain composite materials from lignocellulosic raw materials.

Process scheme for obtaining of wood laminate by using bioadhesive containing microbal polysaccharides 

Process scheme for obtaining of moulded composite materials by using of bioadhesives obtained from organic waste material.

Process scheme for obtaining of water proof composite materials from yeast waste

BIOTECHNOLOGY OF MICROBIC POLYSACCHARIDES 

The Chair of biotechnology, bioengineering and biochemistry has conducted researches and studied xanthan, dextran, alginate, levan and bacterial cellulose. 

Bacterial cellulose is a promising material for obtaining a wide variety of products and nanomaterials. Its potential as a biomaterial for medical industry and for tissue engineering in particular is great, it can be used to create wound coverings and transdermal therapeutic systems. It can also be used in dietology as a supplements carrier for a balanced diet, or in industrial electronics for obtaining of optically-transparent compounds with an extremely low temperature expansion coefficient, or acoustic diaphragms; it can also be a substitute for vegetable cellulose in paper manufacturing. Bacterial cellulose is a promising source of nanocrystal cellulose and biocomposite materials. 

The Chair has obtained a new producer of bacterial cellulose-Gluconacetobacter sucrofermentans B-11267 (patent RU 2523606). The technology for obtaining of bacterial cellulose from industry waste (patents RU 2536973, 2536257) was developed. The samples of bacterial cellulose were tested and the biocomposites based on them were successfully obtained (patent RU 2564567). 

Xantan is a biopolymer of microbic origin which is widely used in food, petroleum, pharmaceutical, mining, textile and coating industry. Xantan is ecologically friendly , non-toxic (used in food industry as a stabilizer and a thickener E 415), it doesn’t affect the processes of oil extraction and processing and it is permitted to use at Russian oil-extracting enterprises. 

Some highly-productive strains of Xanthomonas campestris were obtained as a result of selection, they produce up to 26 grams of xantan per liter. Two certificates of strains’ deposit have been received. The Chair has studied morphological and physiological-chemical properties of bacteria and has optimized the conditions of their storage. The technical specification for xantan’s production was developed. To lower costs of production it is recommended to use media that contain waste from various biotechnological manufactures. Tests of polysaccharide on linear models of formations have shown that the preparation obtained had filtration and oil-sweeping properties of the same level as of the French-produced polysaccharide Rodopol-23P. Xantan’s production in Russia will allow ceasing the importation of it from abroad.

Gel-membrane of bacterial cellulose                            Xantan powder

Process scheme for xantan production 

BIOTECHOLOGY OF NANOCOMPOSITE MATERIALS BASED ON NANOCRYSTAL CELLULOSE

The Chair of biotechnology, bioengineering and biochemistry is carrying out allocation of nanocrystal cellulose from bacterial cellulose. 

Cellulose is one of the most widespread polymers naturally. For a long time vegetable cellulose has been used in paper production mostly. Cellulose’s fibril contains sections with crystal and amorphous structure. Crystal part of cellulose is very durable and can be compared with the durability of high tensile steel or of Kevlar thus making it possible to use nanocrystal cellulose as a nanosized improver to increase mechanical properties of composite material or on its own as a separate material. 

At the present day carbon nanotubes, graphitized nanofibers, nanotubes with grafted layers and functional groups are used as a nanosized filler in the process of development of composite material. 

As an alternative to nanotubes nanocrystal cellulose can be used, it is obtained from variable renewable sources such as wood, plant raw material or bacterial cellulose. Having such a variety of raw material like this makes producing of nanocrystal cellulose economically more profitable than producing of nanotubes, and high mechanical properties of nanocrystal cellulose maske it possible to say that it is a prefect material for increasing of the mechanical properties of nanocomposite materials. 

Using of bacterial cellulose with long fibrils and a high degree of crystallinity allows obtaining of nanocrystal cellulose with a higher correlation between nanocrystal’s length and width. It is believed that increased length of nanocrystal cellulose makes it more durable. 

Nanocrystal cellulose is used as nanosized additive for increasing of strength properties of nanocomposite material obtained from polyvinyl alcohol that is used in production of aerogel. Aerogel’s low thermal conductivity and density makes it an outstanding heat-sealing material and due to its high-surface area it can be also used as an adsorbing material in water and air purification from organic and non-organic pollution agents.

STUDYING OF MOLECULAR AND CELLULAR MECHANISMS OF EXCITATION, DEGENARATION AND REGENERATION OF EXCITABLE FORMATIONS. 

The Chair of biotechnology, bioengineering and biochemistry has been carrying out the researches of influence of biologically active compounds on the structure, protein-lipidic composition and the functioning of a damaged peripheral nerve. 

The role of meylin sheath of the nerve and its neuroglia in degenerative and regenerative processes is also studied. 

The stimulatory effect of xymedon, laminin, hyaluronic acid and resveratrol on the processes of regeneration has been studied as well as their normalizing effect on the composition of lipids and proteins, protein-lipidic interaction and lipid peroxygenation in damaged peripheral nerves. 

STUDYING OF MECHANISMS OF THE ERYTHROCYTES OXYGEN-TRANSPORTING FUNCTION’S REGULATION

The Chair uses a wide variety of physical and physico-chemical methods to study the mechanisms of regulations of oxygen-binding and oxygen-transporting functions of erythrocytes thus trying to find new natural compounds of flavonoid origin to improve the transporting function of hemoglobin; the mechanisms of cellular death are also studied according to the RSF research project №15-15-10025. 

It was found out that peripheral vascular diseases alongside classic mechanisms of progression are often accompanied by pathological changes in erythrocytes such as structural and physiological reconstruction of hemoglobin. 

New information on the erythrocyte’s denucleation and structural-functional state of membrane after apoptosis induction was obtained. The Chair was the first to study the ejection of pigeon’s erythrocytes nuclei followed by disintegration of cells to apoptotic vesicles. Fatty acid composition of several lipidic fractions under the influence of hydrogen peroxide and UV irradiation has been studied. The induction of apoptosis by sphingomyelin, phosphatidyserinem, diacyglycerol and oleic acid. The connection between erythrocytes apoptosis and the changing of membranes lipidic components was found. 

a b

c d

Representation of human erythrocytes obtained via CR-spectroscopy 
a-healthy person; b, c-blood vessel disease patients; d-patients after treatment

LABORATORY EQUIPMENT OF BIOTECHNOLOGY, BIOENGINEERING AND BIOCHEMISTRY DEPARTMENT

The department includes several laboratories such as fundamental biotechnology lab, microbial polysaccharides lab, biocomposites lab, laboratory of physical and chemical methods of analysis, fermentive biotechnology lab, biological products lab, laboratory of biophysics, cell biochemistry lab that are fitted with modern analytical equipment for chromatographic, spectral, morphological, biochemical, biophysical and microbiological researches and also with biotechnological equipment and material testers.

Chromatographic Equipment List:

– LC-20A high-efficient liquid chromatograph with refractometric and UV-detector (Shimadzu, Japan); 
– GC-2010 Plus gas chromatograph (Shimadzu, Japan), 
– LC-20AD liquid chromatograph (Shimadzu, Japan); 
– Kapel’-105 capillary electrophoresis system; 
– ASE 150 automatic extractor.

Equipment Description

LC-20AD liquid chromatograph

Configuration of the liquid chromatograph includes pump, low pressure quaternary gradient valve, systemic controller, vacuum degasifier, column heating oven, spectrophotometric detector, refractive index detector, samples manual batcher, device operation and data processing software, chromatographic columns and pre-columns. The device is capable of defining carbohydrates and hydrocarbons.

GC-2010 Plus chromatograph

Gas chromatograph with flame-ionizing detector, split/splitless injector, GOST 51483-99 columns, compressor, hydrogen generator, set of filters for gas purification. The device is capable of defining methyl ethers of fatty acids, acetates, natural styrenes, alcohols.

Kapel’-105 capillary electrophoresis system

The system is intended for cations, vitamins, colorants, preservatives tests for drinks, water (drinking and waste), food and fodder products.

ASE 150 Automatic Extractor

The extractor is intended for cations, vitamins, colorants, preservatives tests for drinks, water (drinking and waste), food and fodder products.

Spectrometric Equipment List:

– InfraLUM® ФТ-10 infrared analyzer, 
– optical set for registration of absorption in UV and visible range of spectrum with parallel fixing of pH value and oxygen concentration in fluid environments (Ocean optics, USA); 
– UV-Mini-1240 UV-spectrophotometer; 
– UV-3600 spectrophotometer; 
– RF-5301PC spectrofluorometer; 
– IRPrestige-21 infrared Fourier spectrophotometer.

Equipment Description

IR Prestige-21 IK-Fourier spectrometer

Infrared spectrometer with Fourier transform, single-beam, with alignment optics and external beam lead, with possibility of spectral range expansion to near and far IR-areas by means of basic blocks from spectrometer manufacturer complete with a KBr demountable cell, a film holder, a tablet holder and a press. Minimal resolution in middle (standard) and far (option) infrared bands is not more than 0,5 cm-1; capability to work with resolution of 1; 2; 4; 8; 16 cm-1. Resolution in near (option) infrared band is not more than 2 cm-1; capability to work with resolution of 4; 8; 16 cm-1. Ratio of signal to noise is not less than 40000:1 (4 cm-1, 1 min., 2100 cm-1, measured as peak to peak). Adjustment of intensification coefficient in the range of 1-128 is automatic or manual at the choice of operator.

UV-3600 spectrophotometer

The device for spectrometric researches possesses the following principal specifications: dual-beam, scanning; double monochromator, concave grating premonochromator and Curny-terner monochromator with aberration correction; three detectors: PMT, InGaAs, PbS; radiation sources: deuterium arc lamp and halogen lamp of not more than 50 W power, automatic adjustment; spectral band of 185–3300 nanometers; 8-grades band gap: from 0,1 to 8 nanometers in UV / visible range, 10-grades band gap: from 0,2 to 32 nanometers in near IR area; spectral resolution of 0.1 nanometers; scattered radiation level of no more than 0,00008% (220 nanometers), 0,00005% (340 nanometers), 0,0005% (1420 nanometers), 0,005% (2365 nanometers); wavelength setting accuracy is not worse than ± 0,2 nanometers (UV and visible areas), ± 0,8 nanometers (near IR area); wavelength setting reproducibility is not worse than ± 0,08 nanometers (UV and visible areas), not worse than ± 0,32 nanometers (near IR area); baseline drift is no more than 0,0002 a.u. / hour; noise is not more than 0,00005 Abs (500 nanometers), 0,00008 Abs (900 nanometers), 0,00003 Abs (1500 nanometers) (root-mean-square value at 0 Abs, a gap of 2 nanometers, 1 s) absorbance units; scanning speed in continuous scanning mode is a variable from 4500 nanometers/min. and less for UV and visible band; from 9000 nanometers/min. and less for the near infrared band blocked by PMT and InGaAs detectors; from 4000 nanometers/min. and less for the near infrared band blocked by PbS detector; wavelength reorganization speed in the mode of wave to wave transition is 18000 nanometers/min. less for UV and visible band; 70000 nanometers/min. for near infrared band; automatic switching of radiation sources, at the choice of operator in the range of 282-393 nanometers, with 0.1 nanometers discretization; photometric range is from -6 to +6 Abs; photometric accuracy is ± 0,002 a.u. (at 0,5 a.u.) and ± 0,003 a.u. (at 1,0 a.u.); photometric reproducibility is ± 0,0008 a.u. (at signal quantity of 0,5 a.u.) and ± 0,0016 a.u. (at signal quantity of 1,0 a.u.); scanning and band transformations at various speed, comparison of various spectra, possibility of spectral foldover, automatic spectrum scaling, normalization, indication of maxima/minima, area determination, derivation to the 4th degree, smoothing, rooting, logarithmation, Kubelka-Munk transformation, averaging, interpolation; kinetic measurements such as measurement of absorption dependence on time, determination of enzymatic activity, one - or two-wave measurements, calculations according to Michaelis-Menten, creation of graphs (according to Michaelis-Menten, Lineweaver-Burk, Hannes, Wolf, Eadie-Hofstee), Dixon and Hill graphs, reagent input registration at measuring; quantitative analysis – the analysis according to calibration curves from 1 to 3 orders on the K-factor, measurements on 1–3 wavelengths, averaging of results; report preparation.

RF-5301PC Spectrofluorimeter

The RF-5301PC spectrofluorimeter is intended for carrying out quantitative and qualitative analyses by the method of measurement of fluorescence radiated by the substance irradiated by a light source.

– The source of radiation is 150 W xenon lamp with a deozonator.

– F/2.5 exaltation and emission monochromators with concave concentrating holographic gratings, 1300 slits/mm.

– Spectral range of measurement is not narrower than 220-900 nanometers and zero order.

– Wavelength scale: 220–990 nanometers.

– Detector: photo multiplier.

– Crack width is 1,5; 3; 5; 10; 15 and 20 nanometers.

Scanning speed in the mode of continuous scanning is 7 speeds from 5500nm/min and lower.

– Installation speed on the chosen wavelength is 20000 nanometers/min.

– Inaccuracy on wavelengths scale is not more than ± 1,5 nanometers.

– Excitation energy compensation method: return coupling to the metering photo multiplier, monitoring of monochromatic radiation.

– Sensitivity: ratio size signal/noise is 150 for Raman band of distilled water (350 nanometers, 5 nanometers crack, 2 c time constant).

– Time constant is 0,02; 0,03; 0,1; 0,25; 0,5; 2; 4 and 8 sec.

– Sensitivity ranges: two ranges of sensitivity – "High" and "Low" (50 times difference).

"InfraLYUM® FT-10" infrared analyzer

Fixed laboratory instrument which can quickly define the structure and quality of such products as wheat, barley, rye, oats, wheat and rye flour, fodder yeast, compound feeds, powdered milk, cottage cheese, cheeses, cheese masses, mincemeat, etc. The majority of types of tests are analyzed without preparation.

UV-Mini-1240 one-beam scanning spectrophotometer

List of Equipment for Microbiological Researches:

–Biostat Aplus bioreactor with 1 l. working volume; 

– BIOSTAT® PBR-2-S bioreactor with 3 l. working volume; 

– BIOSTAT Bplus bioreactor with 5 l. working volume;

– BIOSTAT Cplus bioreactor with 30 l. working volume ("Sartorius", Germany);

– ES-20/60 BIOSAN shakers incubators; 

– thermostats; 

– MLR-351H climatic chamber (Sanyo, Japan); 

– automated interference microscope on the basis of МИИ-4М microscope; 

– Micros (Austria) and Unico (the USA) microscopes with digital visualization systems;

– TFD8503 freeze dryer; 

– Vi-CELL XR cell viability analyzer.

– Countess automatic cell counter;

Equipment Description

BIOSTAT® Aplus fermenter (bioreactor)

It is intended for cultivation of microorganisms in aerobic and anaerobic conditions. It is equipped with рН, temperature, oxygen monitoring.

BIOSTAT® Bplus Fermenter (bioreactor)

BIOSTAT® Bplus is a laboratory fermenter created for solution of a wide range of research tasks, improvement of existing productions and also for receiving small lots of products. The main unit of BIOSTAT® Bplus fermenter is made of stainless steel and has a color graphic touch display. BIOSTAT® Bplus fermenter is manufactured in the form of unary (Single) or double (Twin) configuration.

Areas of application: works with microorganisms and cell cultures; research works for industry and science; experiments on scaling at transition from a shaker with flasks; development of fermentation processes and their optimization; small-scale production.

Features: systems for working with one (Single version) or two culture bottles (Twin version); culture bottles with working volume from 1 l to 10 l with a holder for bottle storage, handles and a sampling system; monitoring of temperature, рН, dissolved oxygen, level, foam, Red/Ox, turbidity, mixture and gases consumption; mixer drive with mechanical gasket (speed interval is from 20 to 2000 rpm), a bubbler; sterile filters and a coming-out gases condenser.

Systems and strategy of aeration depending on a range of application: for microorganisms: O2 Enrichment; Gas Flow Ratio Control; for cell cultures: Exclusive flow; Additive flow; "bubble-free" aeration for cell-like cultures through a semipermeable membrane; thermostatic system with an integral pump; all vessels are accessible with jackets or without; the device case is made of steel, suitable for cleaning; modern convenient touch display for process control; possibility of padding sensors connection for measurement of optical density of the environment and the count system of Red/Ox-potential, weight sensors; MFCS/DA software for visualization and data processing.

BIOSTAT® Cplus Fermenter (bioreactor)

BIOSTAT® Cplus is a reliable fermenter-bioreactor sterilized in-place with vessels working volumes of 2 liters to 30 liters. BIOSTAT® Cplus is developed taking into account modern technologies and directions of design. The completed and ready to work systems include all necessary components for reliable and convenient work with microorganisms or cell-like cultures. Besides, the philosophy of BIOSTAT® Cplus modular design allows developing individual configurations for specific applications.

Ranges of application: pilot production; manufacture processes development; small-scale production.

Features: desktop version with working volumes of 2 l and 5 l; special open frame design, providing working space economy and service convenience, for culture bottles with working volumes of 10-30 l; the main unit, feeding lines and fermenter are made of stainless steel for mild processing; possibility of choice from four strategies of gas supply; color graphic touch control display; possibility of heating type choice  – either electric or steam; sensors of temperature, рН, dissolved oxygen, foam level and culture liquid, mixer drive with mechanical or magnetic seal, a bubbler, sterile filters and a coming-out spent gas cooler; management and control of stirring speed, рН, concentration of dissolved oxygen, temperatures, supply of substratum and defoamer, gas mixture composition, etc.; possibility of padding sensors connection for measurement of optical density of the environment and Red/Ox-potential; MFCS/Win software for visualization and data processing.

Automated interference microscope on the basis of MII-4M microscope

The microscope gives the chance to study living unpainted cells, to carry out cells morphometry, index of double refraction, assessment of cell population condition, and also to carry out dynamic phase microscopy.

Micros MC 100 (TS) Video Set

With the help of video camera and trinocular head the image is displayed on the monitor and checked in real time.

BIOSTAT® PBR 2 S fermenter (bioreactor)

BIOSTAT® PBR 2 S fermenter (bioreactor) of 3 l with a photoluminescent block for photosynthesizing microorganisms cultivation

It is intended for photosynthesizing microorganisms cultivation in aerobic and anaerobic conditions. It is equipped with рН, temperature, oxygen, turbidity control.

MLR-351H Climate Chamber

Cultivation of plants in different conditions of illuminating intensity, humidity and temperature for biological products testing. Besides, it can be used as luminostat for cultivation of water fleas, algas (for water biotesting).

SANYO, MDF-U53V vertical low-temperature deep freeze

The device creates stable low-temperature environment with minimum temperature fluctuations that makes it ideal equipment for storage of blood cells and biological exemplars sensitive to temperature variations.

It provides cooling temperature up to – 860C and stable long-term storage.

FD freeze dryer

Deaquation of biological objects: fabrics, proteins, nucleic acids, vaccines and so forth by a liophilisation method (cryogenic exsiccation of frozen biological products in vacuum) for the purpose of their long-term storage.

Using of the freeze dryer guarantees: high-quality and fast bioobject drying; retention of biopolymer structure in the course of liophilisation; preservation of biological activity of dried-up biological product in the course of long-term storage.

MLS-3781L upright autoclave

ES-20/60 shaker-incubator

It provides smoothly (or intensive) stirring in the flasks installed on the platform.

Vi-CELL XR cell viability analyzer

It defines the quantity of living and dead cells and the total amount of cells using trypan blue.

COUNTESS automatic cell counter

It defines the quantity of living and dead cells, and also the total amount of cells, using trypan blue.

PHOTOCOR COMPLEX modular spectrometer of dynamic and static light scattering for nanoparticles size measurement

Modular spectrometer of dynamic and static light scattering for nanoparticles size measurement is intended for measurement of sizes and diffusion coefficients of nanoparticles in dispersions and definitions of molecular characteristics of polymeric molecules, terminating particle sizes in the range from 0,5 to 6000 nanometers.

PM 400 Planetary Mill (Retsch, Germany)

PM 400 planetary mill with grading limit of less than 1 micron.

Equipment List for Bioplastics Manufacture and Tests:

– GT-7014-H50C thermohydraulic hot isostatic press for polymers with independent cooling system and LC control panel;

– GT-7016AR pneumatic stamping press for exemplars; UAI-7000M universal double-column testing machine; 

– stretch testing machine, ultimate stretch/gap strength, flaking off, seam durability, tearing, polymeric films XLW (PC) – Auto puncture;

– analyzer of mechanical strength characteristics of HTT-L1sheet coverings fresh seals; 

– VT-04F portable rotor viscosimeter for viscosity test of dispersions and quality control; 

– CZY-6S device for determination of stickiness/adhesion; 

– CHY-C2 automatic high-res thickness meter; 

– MS-70 thermo-grav humidity analyzer; 

– H-200L automatic high-res densitometer; 

– GT-7090-H thin-film thermotester for shearing deformation definition at elevated temperature; 

– Hamilton Beach triple-spindle mixer; GT-7017 M heat ageing oven; 

– FPT-F1 device for friction coefficient definition and flaking off test.

Equipment Description

CHY-C2 automatic high-res thickness meter

It is intended for measurement of thickness of polyethylene film, foil and other materials with 0,1 microns accuracy.

FPT-F1 measuring device (Taiwan-USA)

It is intended for measurement of coefficient of static and kinetic friction of films, textiles, paper, and also flaking off tests of sticky laminates.

MS-70 (Japan) termogravimtetric humidity analyzer

It is intended for measurement of humidity of solid monolithic, sheet, loose, pasty materials, aqueous slurries and non-aqueous liquids.

H-200L (Taiwan-Germany) automatic high-res densitometer

It is intended for determination of specific weight and density of materials in the form of granules, flakes, powder.

CZY-6S Device (China-USA)

It is intended for determination of stickiness of adhesives, sticky surfaces under the influence of shearing strain.

UAI-7000 М (GOST 28840) (Тaiwan-USA) universal testing machine

It is intended for tests on stretching, compression, shift, tensile strength, etc. for exemplars of rubber, plastic, composites, fabric, paper, film, textiles.

XLW (РС)–Auto device (China-USA)

It is intended for tests of polymeric films, flexible packing materials, adhesives, adhesive tapes, glues, rubber, paper for stretching, tensile strength, flaking off at the angle of 900 and 1800, seam durability, shift/cut, puncture.

GT-7014-Н50С (Taiwan-USA) thermo-press

It is intended for molding of exemplars of polymeric materials, composites in an open compression mold at given temperature and pressure with molding time monitoring.

GT-7016AR (Taiwan-USA) pneumatic punching press

It is intended for preparation of exemplars of composition polymeric materials for tests.

Equipment for Biophysical Researches

PFP-7 (Jenway) Flamephotometer

Operating mode is flame-emission; semi-automatic ignition system; thermocouple temperature monitoring; automatic interruption of gas supply in case of flame failure.

The device is developed for determination of sodium and potassium content in dispersions and biological liquids. It is also possible to determine lithium, barium and calcium with the help of padding filters.

Measuring range of weight percentage of Na (K) is 0,5... 1000 (400) mg/dm3. The limit of Na and K detection is 0,2 ppm. The limit of Li detection is 0,25 ppm. The limit of Ca detection is 15 ppm. The limit of Ba detection is 30 ppm.

Binder KB 23 thermostat

Application: carrying out tests and maintaining precise heating environments. Chamber volume is not less than 20 l. Temperature range is from 00C to 1000C. Programming: 2 programs each consisting of 10 sections; automatic switching to 1 program from 20 sections.

ATAGO AP-300 automatic polarimeter

Measuring: rotation angle of polarization plane; international sugar scale (without temperature compensation); international sugar scale (with automatic temperature compensation); specific rotation; concentration and degree of purity.

Measuring range: rotation angle of polarization plane angle: –89,99 … +89,990; international sugar scale: –130,00 … + 130,000Z. The range of temperature correction for international sugar scale: 18÷300C. It is intended for study of optically active substances dispersions, such as sucrose, glucose, protein.

S70-K Mettler Toledo conductometer

It is intended for analysis of dispersions and water direct-current conductivity, determination of common salinity and for water quality test.

Characteristics: big LC display, RS 232 interface; direct-current conductivity measuring range is from 0,01 mmho/cm to 1000 mmho/cm; common salinity is from 0,01 mg/l to 1000 g/l; fixing of observed data is automatic, manual or timed.

Sorvall RC-6 Plus High-speed Centrifuge

Maximum speed is 22000 rpm. Minimum speed is 300 rpm. Maximum relative centrifugal acceleration is 50230 g. Degree of speed regulation is 25 rpm. Microprocessor control. 9 acceleration modes. 10 braking modes. Presence of precooling mode. Presence of timer. Programming of 3 stages of centrifugation in one cycle. Simultaneous display of the given and current parameters: time, temperature, centrifugation speed.

Equipment of Protein Analysis Lab

Gel Doc XR Plus gel imaging system

Gel Doc XR Plus gel imaging system consists of dark isolation ward, CCD camera, a group of lenses with programmatically controlled focusing, a source of ultraviolet and visible light, light filters with particular wavelength. Gel Doc XR Plus gel imaging system gives opportunity of fast visualization, documentation and analysis of proteinaceous and nucleinic gels, and also blots. The system supports the methods of colorimetric and fluorescent definition and densimetry. Gel Doc XR Plus gel imaging system is an ideal addition to PCR, allowing to carry out and document the results of restriction analysis, amplification of nucleic acids, genetic dactylography, polymorphism of restriction fragments length. This system is able to help increase effectiveness of cloning due to protection of DNA against UV radiation by means of XcitaBlue™ filter and use of such colourings as GelGreen, SYBR® Safe, and SYBR® Green I.

Technical features: Maximum size of an exemplar is 28х36 cm. Maximum area of image is 19,4х26 cm. Transilluminator light source with minimum required set of wavelengths of  254, 302, 365 nanometers, colorless light. CCD camera detector with possibility of signal accumulation. Resolution is 1360х1024. Image size is 1,4 mp. Number of fluorescence filters is 2. EtBR/SYBR Geen BP emission filters. Possibility of work with colorings SYBR Geen BP, SYPRO Ruby, Rodamine, calculation of colonies, silver coloring, green fluorescent proteins, Coomassie Brilliant Blue. System sensitivity is possibility of detection 0,1 ng of two-chain fragment of DNA at not less than 400 mcLux without signal accumulation. Possibility of work with color images, automatic accumulation of signal from a weak exemplar, quantitative analysis of molecular weight and length of a fragment, integration into an intra laboratory network, archiving of results.

BioLogic LP System chromatographic low-pressure system

BioLogic LP System chromatographic low-pressure system with BioFrac fractions collector and software is used for biomolecules cleaning. The system has two light filters with wavelength of 254 and 280 nanometers for detection of nucleic acids and proteins, and also a conductometric cell for monitoring of gradient progress. The peristaltic pump of the system allows supporting flow rate from 0,05 to 40 ml/min. with flow rate adjustment of 0,01 ml/min. Maximum created pressure makes 0,2 MPas (30 psi).

The system is compatible with Econo low pressure columns, UNOsphere, Bio-Gel, Macro-Prep carriers and other carriers for low pressure chromatography. Presence of SV-5 valve for buffer choice allows using up to 5 buffers in the course of biomolecules cleaning. The system allows carrying out biomolecules fractionating in the modes of complete collecting, threshold collecting, window collecting and a combination of these methods. The system is compatible with all known solvents and allows keeping up to 50 cleaning methods in memory. BioLogic LP System chromatographic low-pressure system is installed in a refrigerator room with controlled temperature from +1 to + 80C with a step of  0,10C.

Protean i12 IEF System for isoelectrofocusing

Protean i12 IEF isoelectrofocusing system allows defining isoelectric point of proteins with the help of strips having immobilized pH gradient. Isoelectric focalizing can serve as the first direction at two-dimensional electrophoresis which is a potent tool in protein researches. Besides, this system can be used for composite proteinaceous systems analyses, for identification of specific targets and markers.

Advantages of Protean i12 IEF system: 1. Fast optimization of experiment. The system allows carrying out the analysis of an exemplar under different conditions during one experiment. Different gradients of pH and different protocols can be used at the same time; 2. Receiving high-quality results with the least experimental risk is reached due to use of independent channels; 3. Easy, intuitive programming.

Mini-Protean Tetra Cell Chambers for vertical electrophoresis

Mini-Protean Tetra Cell 4 gels chambers for vertical electrophoresis, 10 holes chaser,1 mm gel thickness and Wide Mini-Sub Cell GT for horizontal agarose gel, 15х10 cm gel size, 15 and 20 holes chaser.

MiniSpin laboratory cenrifuge

Maximum centrifugation speed is 13400 rpm. Maximum acceleration is 12100 g. Automatic opening at the end of centrifugation. Angular rotor for 12 test tubes up to 2,0 ml.

TLC-Sampler 4 automatic applicator

ATS 4 is used for completely automatic application of samples, for qualitative and quantitative analysis, and also for preparation purposes. It is suitable for routine application and for high-performance screening. Samples can be put as "spots" by a contact method (0,1–5 mcl) or in the form of dashes or boxes (from 0,5 to 50 mcl) by a spraying method.

Features: Completely automatic application of samples for routine analysis. Application of samples in the form of "spots", dashes and boxes. Input of parameters and monitoring of work with the help of winCATS software. Putting dispersions on any flat objects. Application of samples by a contact method in the range from 0,1 to 5 mcl. Application of samples by a spraying method in the range from 0,5 mcl and more. Automatic autosampler-applicator  TLC Sampler ATS 4 with winCATS conforms to requirements of GMP/GLP and can be qualified as IQ/OQ. Assessment of plates by classical densitometry.

The laboratory is completely equipped for instrumental TLC and is capable of working both with classical densitometry and digital image processing.

 AMD 2 System: gradient eluating in HELC

CAMAG AMD allows solving problems which cannot be received by means of routine TLC. Only by means of AMD it is possible to carry out the reproduced gradient eluating on plates with silica gel. Gradient eluating in HELC is carried out only with is reverse - phase columns, but not with silica gel for which gradient eluating is not acceptable. For HPTLC it is not critical.

AMD = Automatic Multiple Development.

Operating principle of CAMAG AMD:

• HPTLC plate elutes multiply in the same direction. In each subsequent step the distance of the front increases.

• Upon termination of each step eluent is completely removed from the plate by chamber pumping out.

• In each subsequent step polarity of eluent decreases and a so-called graduated gradient is formed.

• The combination of "focalizing" effect and gradient eluating allows receiving very narrow zones with peak width of about 1 mm which means complete division up to 40 components at the distance of 80 mm.

AMD 2 is operated with the help of winCAT S software. The gradient task to 5 solvents is put from the program and displayed graphically along with front distance. Implementation of eluating program is carried out completely automatically.

Equipment of Cell Biochemistry Lab

Renishaw inVia Raman Microscope

InVia Basis system is intended for Raman spectral analysis with exaltation wavelength of 532 nanometers, includes Leica adapted microscope of research class, CCD matrix spectrometer of 1024х256 pixels with Peltier-cooling up to – 700C.

Raman spectroscopy displays vibrations of molecules and crystals. On the basis of this information it is possible to identify substances and also to define other important characteristics, for example, the level of tension in crystals.

Highly sensitive detector inVia with Peltier-cooling and efficient optical filters provide high proportion of signal/noise; qualitative data even from tiny traces of studied material are obtained. High spatial and spectral resolution is standard for the patent scheme EasyConfocal™. It is easy to obtain excellent data as fast as possible even from exemplars with big area and volume. InVia uses the patent SynchroScan™ technology for record of bands in the widest range without the influence of artifacts bound to spectra links which are put down in different ranges which makes inVia ideal not only for Raman spectroscopy, but also for photoluminescence research.

IVIS Lumina II molecular imager

It is equipped with a highly sensitive CCD camera for scientific researches with inverse matrix flare (Back-thinned CCD, back-illuminated CCD), a set of 10 exaltation filters (430, 465, 500, 535, 570, 605, 640, 675, 710, 745 nanometers, a set of 4 emission filters: 515–575 nanometers, 575–650 nanometers, 695–770 nanometers, 810–875 nanometers.

The system has to be intended for receiving and analysis of fluorescent and bioluminescent images of small laboratory animals in vivo.

IVIS® Lumina II (Lumina) is highly sensitive in vivo visualization technological platform with low level of noise which allows carrying out noninvasive visualization and tracking of cells and genetic activity in real time.

Particular genes, cells or organisms "are marked" with a genetic code of one of luciferase enzymes that provides luminescence of some bacteria, insects and animals. When the marked organism is active it shines. Emitted light corresponds to number and position of the marked organism. This information allows scientists to observe noninvasively the spread of illness or the effect of a medicine in the whole system.

IVIS Lumina allows receiving images even at a very low level of illuminating intensity which then can be kept and displayed for subsequent analysis. In addition to bioluminescent image, IVIS Lumina also includes equipment for XFO-12 fluorescence which allows visualizing fluorescent possibilities for in vitro and in vivo of appendices. The range of sensitivity of a CCD camera allows using wavelength from 400 up to 950 nanometers for fluorescence.

IVIS Lumina integrated visualization system includes:

1. CCD camera of scientific class cooled thermoelectrically and installed on the lightproof visualization camera.
2. Camera power supply.
3. Computer system on the basis of Windows® for data collecting and analysis.

Agilent (ex-Varion) Cary Eclipse spectrofluorometer

Spectral range of the device is from 190 to 1100 nanometers with the guaranteed photometric characteristics in the range from 200 to 900 nanometers, WinUV Bio Package (WinXP OS) software which includes the following modules:

– scanning;

– concentration;

– kinetics;

– lifetime;

– measurements on the given wavelength;

– measurements at temperature change.

SERVICES PROVIDED BY THE CHAIR OF BIOTECHNOLOGY, BIOENGINEERING AND BIOCHEMICSTRY

LAB OF INDUSTRIAL BIOTECHNOLOGY

Room 106. Lab of fermentative biotechnologies

Services:

1. Production and realization of small consignments of ferments, yeast, blue-green algae and other phototrophs, preparations for soil and effluent treatment, feeding preparations, etc. Equipment: bioreactors BIOSTAT® A PLUS (effective volume 1 liter) and BIOSTAT® PBR 2 S (effective volume 3 liters) that are used for photosynthetic germs’ cultivation both in aerobic and anaerobic conditions. Equipped with pH, temperature, oxygen and turbidity controls.

2. Carrying out the researches in field of (fermentative) technological processes’ development and scaling. Equipment: Bioreactor BIOSTAT® A PLUS (effective volume 1 liter).

3. Analysis of beverages, food (potable and sewage); cationic composition, vitamins, coloring and preserving agents of feeding and alimentary products. Equipment: System of capillary electrophoresis Kapel-105.

Room 108. Laboratory of biopreparations.

Services:

1. Determination of composition and quality of feeding and alimentary products (wheat, barley, oats, rye and wheat flour, feed stuff, desiccated milk, etc.). Equipment: IR Analyzer InfraLUM® FT-10.

2. Testing of biopreparations for plant protection. Cultivation of plants in controlled lightning, humidity, temperature conditions. Equipment: Climate Chamber MLR-351H. It can also be used to cultivate daphnids and algae (while the biotesting of water is in progress).

3. Nitrogen determination in liquid and solid samples (in food and alimentary products). Equipment: automatic unit for Kjeldahl’s steam distillation PRO-NITRO A.

4. Production and realization of small consignments of biopreparation for plant protection. Equipment: Bioreactor BIOSTAT® A PLUS (effective volume 1 liter).

LABORATORY OF NANOBIOTECHNOLOGY

Room 110. Laboratory of microbic polysaccharides.

Services:

1. Selective works with germ cultures.

2. Collecting of germ cultures.

3. Obtaining of pure strains and germ cultures associations from natural environments. 

4. Analysis of microbic compositions of food and feeding products. 

5. Biodeterioration analysis.

Equipment: Laminar flow units, thermostats, microscopes, shakers, freeze storage plants.

Room 111. Laboratory of fundamental biotechnology. 

Services:

1. Control of cells viability and cells number (for nuclear cells). Equipment: Cell viability analyzer Vi-CELL XR.

2. Production and realization of small consignments of polysaccharides. Equipment: Bioreactor BIOSTAT® A PLUS (effective volume 1 liter).

3. Analysis of carbohydrate, protein, lipid composition of various samples (plant raw material for alcohol industry, food products, experimental biopreparations, etc.). Equipment: Liquid chromatograph LC-20 A Prominence. 

Room 113. Laboratory of nutritional media. 

Services:

1. Sterilizing of various materials. Equipment: Vertical autoclave (automatic model) MLS-3781L.

Room 114 (b). Laboratory of lyophilisation. 

Services:

1. Lyophilisation of cultures, polysaccharides, proteins, biopreparations, etc. Equipment: Freeze-drier FD MII-4M.

Room 115. Laboratory of microscopy.

Services:

1. Examination of living uncolored cells, morphometry and evaluation of condition of cell pool. Equipment: Automatic interference microscope.

LABORATORY OF BIOCOMPOSITE MATERIALS

Rooms 107, 109. Testing laboratories. 

Services:

1. Molding of polymer materials samples, composite materials in a flash-type mold at designed temperature and pressure during a regulated period of time. Equipment: Heat Press Machine GT-7014-H50C.

2. Testing of tension, pressure, shearing, tear strength, etc. of rubber, plastic, composition material, cloth, paper, membranes and fabric samples. Equipment: multipurpose test machine UAI-7000 M.

3. Tension, durability, tear strength, 90° and 180° peel, seam strength, shift/shear, puncture testing of polymer membranes, flexible packing materials, adhesives, adhesive tapes, glues, rubber, paper. Equipment: XLW (РС) – Auto.

4. Peel, shift/shear, tension testing of adhesive, layered, plastic films, paper and other flexible materials; testing of weld joint efficiency. Equipment: analyzer HTT-L1.

5. Testing of glue, paints and ointments’ viscosity. Counting slot of 0,3~13, 3~150, 100~4000 mPas/sec. Equipment: Viscometer VT-04F.

6. Testing of adhesives and adhesive surfaces’ tack under shear deformation. Equipment: CZY-6S.

7. Thickness gauging of polyethylene film, foil and other materials accurate to 0,1 micron. Equipment: CHY-C2.

8. Humidity measurement of solid, sheet, bulk, spread materials of water suspension and non-aqueous liquids. Equipment: Thermogravimetric humidity analyzer MS-70.

9. Specific gravity and density testing of granules-, scales- and powder-like materials. Equipment: High resolution automatic density analyzer H-200L.

10. Testing of deterioration of various materials by forced convection and circulation. Equipment: GT-7090-H.

11. Measurement of static and kinetic friction coefficient of films and fabrics; peel testing of adhesive layered materials. Equipment: FPT-F1.

Room 105. Laboratory of physicochemical methods of analysis. 

Services:

1. Studying of living uncolored cells, morphometry and evaluation of condition of cell pool. Equipment: Automatic interference microscope.

2. HPLC analysis of carbons and hydrocarbons. Equipment: Liquid chromatograph LC-20AD.

3. Gas-liquid chromatography analysis of methyl ethers of aliphatic acids, acetates, vinylbenzene, alcohols. Equipment: Chromatograph GC-2010 Plus.

4. Infrared spectrometer analysis of dry powders and films with Fourier transform. Equipment: Infrared Fourier spectrometer IR Prestige-21.

5. Spectrophotometric analysis (190-1300 nanometers) of various solutions. Equipment: Spectrophotometer UV-3600.

SERVICES OF A SMALL ENTERPRISE «BIOZASHITA» FOR 2012-2017

1. Diagnostics of pollution by using fluorescence of chlorophyll of algae and higher plants. 

2. Diagnostics of pathological changes in human and animal blood cells (cardiovascular diseases, oncology, veterinary, etc.): morphology of cells,   membrane condition (permeability, viscosity), proteins’ condition (hemoglobin, albumen).

3. Diagnostics of the effects of anthropogenic factors on human and animal cells and tissue condition.

4. Diagnostics of the effects of optical radiation on DNA and blood cells.

5. Diagnostics of tissue condition by the analysis of phospholipids and fatty-acid composition.

6. Recommendations on medical and preventive biopreparations (pectins, human serum albumin).

STAFF OF THE CHAIR OF BIOTECHNOLOGY, BIOENGINEERING AND BIOCHEMISTRY

ACADEMIC STAFF

Victor Vasilyevich Revin

Born April 12, 1950 in Selishi village in Mordovian ASSR. Graduated from the Department of Chemistry and Biology of the Ogarev Mordovia State University in 1972. Started working in the University in 1972 as an engineer and became a senior engineer of the laboratory of biophysics of the Department of Biology. During the period between 1974 and 1977 was studying at the Lomonosov Moscow State University as a post-graduate student and was then appointed chief of laboratory of biophysics at the Mordovian State University.

Since 1979 V.V. Revin has worked as a teacher: at first as an assistant lecturer, then as a senior lecturer in 1981, in the period between 1983-1990 as an assistant proffesor. After defending his doctoral dissertation in 1990 he started working as a proffesor at the Chair of Biotechology. He is a dean of the department of Biology and Biotechnology and also a chairman of the Chair of Biotechnology, Bioengineering and Biochemistry.

In 1997 V.V. Revin was awarded an Honored Scientist of the Republic of Mordovia; in 2004-a veteran of work of the Ogarev Mordovia State University.

In 1999 V.V Revin was awarded a certificate of honor by the government of the Republic of Mordovia for the immense amount of work he had made to train highly-skilled specialists and for his long-term teaching profession. In 2005 he was awarded an Honored Scientist of Russian Federation and in 2007- an Honored Scientist and Educator of Russian Academy of Natural Sciences. In 2010 V.V. Revin was appointed counselor of Russian Academy of Architecture and Construction Sciences.

Was awarded a Professor of the Year in 2008.

In 2008 he was awarded by the badge «Honorary worker in the sphere of Higher Professional Education»; was awarded by the badge «Honor Roll Student of Higher School of Russia» in 2012; was awarded by the medal «For Merit to Commemoration of Millennium of Unity of Mordovian people with Peoples of Russia». Was awarded by the «Prize of the Head of the Republic of Mordovia» in 2011 and «Laureate of State Prize of the Republic of Mordovia» in 2015.

V.V. Revin is the Head of Mordovian regional office of the National Society of Biotechnology. He is a member of ERO SI of Russia of biological education since 1994 and a member of an Executive Committee of the European Network Thematic Network Association (EBTNA).

Area of expertise

V.V. Revin created an educational research school whose area of focus is priority both in Russia and abroad.

Under his leadership the Chair of biotechnology, bioengineering and biochemistry carries out a wide variety of scientific and practice-oriented researches that are aimed at meeting the needs of enterprises in the Republic of Mordovia and in Russia, and, in prospect, abroad. New strains of germs have been deposited: Fungi Lentius (Panus) tigrinus BKM F-3613 D, Xantamonas Canpestris BKM B-2373 D and others. Among the inventions in sphere of food biotechnology is a sour-milk drink «Zdorovie» that was accepted into production at the Dairy Factory «Saranskii». Some products containing «Modifilan»-natural biologically active product made from brown algae- were also developed and accepted into production at food enterprises of the Republic of Mordovia, for example the products of «Ocean» series. The recipe for a bakery product «Ocean» was developed (TR 9116-002-74638474-07) in 2007 and it was accepted into production at the bread-factory «Khlebzavod» (Saransk, Republic of Mordovia). V.V. Revin supervised the development of the technology of biopreparations for growth stimulation and biological protection of plants from phytopathogens and the technology of recycling of industrial and agricultural waste into feeding preparations enriched with probiotics. He is also conducting another area of research-the development of energy- and resource-efficient technologies for production of ethanol from ultradispersed plant raw material.

Inventions of V.V. Revin have been continually awarded with certificates and medals at various exhibitions: a gold medal of Russian Academy of Architecture and Construction Sciences for the invention of the biotechnology of chipboard materials; medals of the First Moscow International Salon of Innovations and Investments; medals of exhibition «World of Biotechnology» in 2010, 2012, 2013, etc.

V.V. Revin is a Head of government grants from FTP and Russian Science Foundation. 34 million rubles were invested into the research projects that are carried out by the Chair.

His contribution to the development of the technologies for obtaining of microbic polysaccharides (dextran, xantan, levan, alginate, bacterial cellulose), biocomposite materials with biological adhesives based on polysaccharides and germs biomass is truly immense. 

Throughout V.V. Revin’s chairmanship the Chair has undergone a series of effective changes: the Biotechnological Centre was build which later became a base for REC «Nanobiotechnology», three research and three studying laboratories equipped with modern testing units of 100 million roubles worth were created.

V.V. Revin is actively training academic staff. He’s been the academic advisor for 15 Ph. D.’s and 2 Sc. D.’s. V.V. Revin is now an academic advisor for 8 post-graduate students.

Educational activities

The curricula for «Biotechnology» profiles that are used at the Chair headed by V.V. Revin were considered to be the most superlative at the Best Innovative Curricula of Russia Awards in 2011 and 2012. V. V. Revin supervised the creation of the educational standard for major in «Biotechnology with three profiles»: «Fundamental Biotechnology», «Biotechnology of Pharmaceutical Drugs», «Food Biotechnology».

Publications

V.V. Revin has published over 400 of scientific and methodological papers, among them are 14 instructional media, 3 textbooks, 4 monographs and 30 technological patents. More than 30 of his articles have been published in top-rated international journals of the USA, Europe, Japan, etc. His textbook «General Biotechnology» was awarded the 2015 «Best publication in natural sciences» at the 7th National Competitions of publications for Higher Education Establishments.

Davud Ali-Oglu Kadimaliev

Davud Ali-Oglu Kadimaliev was born on 7 November 1952 in the city of Mingachevir in Azerbaijan Soviet Socialist Republic. He graduated form the Department of Physics of the Ogarev Mordovia State University in 1975. He became a Candidate of Biological Science in 1985 and a Doctor of Biological Science in 2003. He was working as an associate professor from 1994 to 2013 when he became a professor. He’s been a professor of the Chair of Biotechnology, Bioengineering and Biochemistry since 2003.

D. A. Kadimaliev is a member of the academic board of the Chair, a chairman of the qualifying commission and of Biological Sciences Expert Board.

He is a member of the Mordovian office of the Russian Society of Biotechnologists and of the Moscow Society of Naturalists.

He’s been awarded certificates of honor by the University, the government of the Republic of Mordovia, AULYCL, the Ministry of Education and Science of the Russian Federation. D.A. Kadimaliev is a recipient of the Ogarev prize and a winner of a national competition in domain of biotechnology and ecology «Engineer of the Year».

Area of expertise: Biotechnology of composite materials, biocatalysts, industrial ecology.

Publications: D.A. Kadimaliec has published more than 170 of scientific papers, among them are 12 patents, 2 monographs, 1 textbook, 3 instructional media (2 rated by ERO of Russia).

He’s been the academic advisor for 3 candidate’s dissertations. He is currently an academic advisor for 1 post-graduate student.

Yuri Veniaminovich Bobrishev

Yuri Veniaminovich Bobrishev was born on 12 February 1956. During the period between 1973 and 1976 studied at the Saint Petersburg State University, got a Master’s Degree in 1978. In 1980-1982 did an advanced training in Pathologic Anatomy at the Pavlov First Saint Petersburg State Medical University and worked as a research assistant at the Biochemistry and Atherosclerosis division of the Research Institute of Experimental Medicine of the North-West Branch of the Russian Academy of Medical Science between 1980-1984.

In 1984 he defended a Candidate of Biological sciences thesis and in 2012 he defended a Doctoral thesis.

Publications: Y.V. Bobrishev has published or contributed to more than 210 papers in peer-reviewed scientific journals; he has filed 6 patents and participated in 17 different grants.

He is currently working as a senior scientific researcher of the Chairs of Anatomy and Surgery at the department of Medicine of the University of New South Wales in Sydney, Australia. He is also working as an associate professor at the School of Medicine of the Western Sydney University.

Y.V. Bobrishev is an honored senior visiting researcher at the Department of Pathological Anatomy in Liverpool, South Wales, Australia.

He is a professor and a Head of the Chair of Cellular Pathology at the Institute of Atherosclerosis of the Skolkovo Innocative Center in Moscow, Russia.

Y.V. Bobrishev is also a professor of the Chair of Biotechnology, Bioengineering and Biochemistry of the Ogarev Mordovia State University.

Nelli Albertovna Atikyan

Nelli Albertovna Atikyan was born on 20 June 1974 in Saransk, Russia. She graduated from the Department of Biology of the Ogarev Mordovia State University in 1996, defended her Candidate thesis in Biological science in 2000 and worked as a senior lecturer between 2000 and 2001. Has worked as an associate professor of the Chair of Biotechnology, Bioengineering and Biochemistry since 2001. N. A. Atikyan is a Chief of Laboratory of Nanobiotechnology at REC «Nanobiotechnology».

Area of expertise: biotechnology, lingolitic fungi and their enzyme systems, industrial microbiology, biotechnologu of bioethanol.

Publications: has published over 100 papers, among them are 15 articles published in VAK journals, 5 instructional media (2 rated by ERO of Russia), 2 textbooks rated by ERO of Russia, 2 monographs, 8 patents.

Natalia Vasilievna Gromova

Natalia Vasilievna Gromova was born on 30 October 1968 in Saransk, Russia. She graduated from the department of Biology of the Ogarev Mordovia State University in 1992. 

A Candidate of Bilogical Science (1998), an assosiate professor (2004), an assosiate professor of the Chair (2010-present).

A member of the Academic Board of the Department of Biotechnology and Biology.

Area of expertise: studying of molecular and cellular mechanisms of regulation of oxygen-transporting properties of erythrocytes’ hemoglobin and of their role in development of pathologic conditions; studying of role of myelin sheath of nerve in degenerative and regenerative processes and functioning of a damaged peripheric nerve.

Publications: over 80 scientific and academic papers, among them are 2 monographs (as a co-author), 6 instructional media.

Arkadii Anatolyevich Devyatkin

Arkadii Anatolyevich Devyatkin was born on 20 December 1975 in Saransk, Russia. Graduated from the Department of Biology of the Ogarev Mordovia State University in 1998. Became a Candidate of Bilogocal science in 2005 and started working as an assosiate professor at the Chair of Biotechnology, Biochemistry and Bioengineering in 2006. Assosiate dean for academic affairs and informatization since 2006.

Area of expertise: physico-chemical and molecular mecganisms of apoptosis, cellular biophysics, biotechnology of  fermentation industry.

Publications: 49 scientific and academic papers.

Elvira Sergeevna Revina

Elvira Sergeevna Revina was born of 3 April 1968 in Temnikov, Russia.Graduated from the Biological (1992) and Medical (1997) departments of the Ogarev Mordovia State University. Became a Candidate of Medical Science in 2000 and an assosiate professor in 2005. Has worked as an assosiate professor of the Chair of Biotechnology, Biochemictry and Bioengineering since 2001. 

A member of the Academic board of the Chair. A member of a jury for final stages of the Academic competition in Biology.

Was awarded Certificates of Merit by the Chancellor of the Mordovian State University and by the Ministry of Education of the Republic of Mordovia.

Area of expertise: the studying of the role of myelin sheath of a nerve and neuroglia in degenerative and regenerative processes in functioning of a damaged peripheric nerve; the studying of mechanisms of regulation of oxygen-binding capacity of hemoglobin, the searching for new natural compounds that affect the functional activity of erythrocytes.  

Publications: over 40 scientific papers, 13 academic papers, 1 monograph (as a co-author), 2 academic papers rated by ERO of Russia.

Marina Romulovna Tairova

Marina Romulovna Tairova was born on 28 December 1957 in Kostanay, Kazakhstan. Graduated from the Department of Biology of the Ogarev Mordovia State University in 1980, became a Candidate of Biological science in 2000 and an assosiate professor in 2005. A member of the Academic board of the Chair of Biotechnology, Biochemistry and Bioengineerng.

Area of expertise: changing of morphometric characteristic of erythrocytes and of conformational properties of hemoglobin’s haemotoporphyrin under the influence of various factors; role of the initial state of haemostatic system in its reactions to physical stress.

Publications: 50 sientific and academic papers, among them are 2 instructional media.

Vitalina Victorovna Shutova

Vitalina Victorovna Shutova was born 3 March 1970 in Saransk, Russia. Graduated from the Department of Biology of the Mordovian State University in 1994, became a Candidate of Bilogical science in 2001 and an assosiate professor in 2012. Has worked as an assosiate professor of the Chair of Biotechnology, Biochemistry and Bioengineering since 2004. A member of the Society of Biotechnologists of Russia and of  National Academy of Micology. Was awarded an Ogarev prize in 2002.

Area of expertise: the researches in sphere of Physiology, Biochemistry and Biotechnology of xilotrophic fungi, bacterial polysaccharides, nanobiotechnologies, obtaining of ecologically friendly biocomposite materials, non-waste biotechnologies and processing of recycable materials of food industry, obtaining of probiotic and feeding products, biotechnologies of milk production.

Publications: over 130 scientific and academic works, among them are 2 monographs, 4 patents, 1 instructional medium, 5 textbooks.

Natalia Alekseevna Melnikova

Natalia Alekseevna Melnikova was born on 29 October 1967 in Saransk, Russia. Graduated from the Ogarev Mordovia State University  in 1991, became a Candidate of Biological science in 1994, an assosiate professor in 1997, an assosiate professor of the Chair of Biotechnology, Biochemistry and Bioengineering since 2015. Awarded a Certificate of Merit by the State Assembly of the Republic of Mordovia in 2012 and a Certificate of Merit by the Government of the Republic of Mordovia in 2015. 

Area of expertise: adaptative reactions of formed elements of blood as a result of the influence of adverse factors; studying of molecular mechanisms of degeneration and regeneration of excitable formations caused by damage and searching for biologically active compounds that modulate their condition.

Publications: over 150 scientific and academic papers, among them are 2 monographs (as a co-author), 10 instructional media.

Svetlana Aleksandrovna Ibragimova

Svetlana Aleksandrovna Ibragimova was born on 18 May in 1972 in Saransk, Russia. Graduated from the Department of Biology of the Ogarev Mordovia State University in 1995, became a Candidate of Biological science in 2003. An associate professor of the Chair of Biotechnology, Biochemistry and Bioengineering since 2005. A Head of the Laboratory of Industrial biotechnology at REC «Nanobiotechnology» since 2011. A winner of the «Lecturer of the Year» award in 2013. Awarded a Certificate of Merit by the Ministry of Industry, Science and New technologies of the Republic of Mordovia in 2014.

Area of expertise: industrial microbiology, bioprotection of plants.

Publications: over 50 scientific works, among them are 2 instructional media, 1 patent, and 1 deposit certificate.

Elena Vladimirovna Liyaskina

Elena Vladimirovna Liyaskina was born on 14 May 1961 in Bukhta Razboynik, Primorski Krai, Russia. Graduated from the Department of Biology of Kazan State University with a degree in Microbiology in 1983. Became a Candidate of Biological science in 1995. An assistant professor of the Chair of Biotechnology, Biochemistry and Bioengineering since 1998. The Head of the Laboratory of Bioobjects Analysis at REC «Nanobiotechnology» since 2013. Awarded a Certificate of Merit by the University and a Certificate of Merit by the government of the Republic of Mordovia.

Area of expertise: microbic biotechnology, bacterial exo-polysaccharides, xanthan, bacterial cellulose, biocomposite materials.

Publications: over 60 scientific and academic papers, among them are 1 instructional medium and 2 textbooks rated by ERO of Russia, 1 electronic textbook, 1 monograph and 5 patents.

Evgeny Vladimirovich Mokshin

Evgeny Vladimirovich Mokshin was born on 20 January 1978 in Saransk, Russia. Graduated from the Department of Biology of the Ogarev Mordovia State University in 2000. Became a candidate of Biological science in 2005. During the period between 2007 and 2014 worked as an assistant professor at the Chair of Botanics and Plants Physiology, and since 2014 - an assistant professor at the Chair of Biotechnology, Bioengineering and Biochemistry. A chairperson of the Council of young scientists from 2002-2009. Vice-chancellor of the Council of young scientists of the Ogarev Mordovia State University from 2005-2009.  Inspector of the Mordovian Regional office of a National non-governmental organization  «Russian Union of Young scientists» from 2005-2009.

A member of the Society of Plant Physiologists of Russia. A member of the Society of Biotechnologists of Russia.

Area of expertise: phytobiotechnology, plant growth regulators, plant cells and tissues culture, invitro technologies, clonal propagation of plants.

Publications: 70 papers, 10 instructional media (including 4 electronic instructional guides), 5 patents.

Nikolai Aleksandrovich Pestov

Nikolai Aleksandrovich Pestov was born on 4 September 1979 in Saransk, Russia. Graduated from the Department of Biology of the Ogarev Mordovia State University in 2001. Became a candidate of biological science in 2005. An assistant professor of the Chair since 2012.

Area of expertise: biotechnology of microbic polysaccharides, obtaining of new functional and constructive composite materials based on nanocrystal and nanofibrillary bacterial cellulose. 

Publications: over 20 papers.

Igor Pavlovich Grunushkin

Igor Pavlovich Grunushkin was born on 17 January 1963 in Saransk. Graduated from the Department of Biology of the Ogarev Mordovia State University in 1985. Became a Candidate of Biological Science in 1997. Subject of Candidate thesis «Changing of the activity of phosphoinositides-specific phospholipase C and amount of diacyglycerol in somatic nerves under excitation».

Senior lecturer of the Chair (1997), an assistant professor of the Chair (2013).

Area of expertise: biophysics, physical chemistry of membranes of nerve tissue, studying of the mechanisms of excitation conduction through neurofibre.

Publications: over 20 papers, including 1 instructional medium.

Oksana Sergeevna Nadezhina

Oksana Sergeevna Nadezhina was born on 17 July 1981 in Komsomolski village in Mordovia, Russia. Graduated from the Department of Biology of the Ogarev Mordovia State University in 2003. Became a Candidate of Biological Science in 2007.

An assistant professor of the Chair since 2011.

Area of expertise: microbic biotechnology, biodegradation of lignocellulosic raw material, sewage water treatment, biotechnology of microbic polysaccharides. 

Publications: over 30 scientific and academic papers. 

Olga Sergeevna Novozhilova

Olga Sergeevna Novozhilova graduated with honors from the Department of Biology of the Ogarev Mordovia State University. In 2007 defended a Candidate of Biological Science thesis in Biochemistry. 

A senior lecturer of the Chair since 2008.

Area of expertise: morphofunctional characteristics of erythrocytes, biologically active agents’ influence on oxygen-transporting functions of hemoglobin.

Publications: over 60 scientific and academic papers, including 1 patent and 1 electronic study guide.

Ilya Vladimirovich Susin

Ilya Vladimirovich Susin was born on 20 February 1989 in Saransk. Entered the Ogarev Mordovia State University in 2006 and graduated from the Department of Physics and Chemistry in 2014. Started his post-graduate studies the same year and completed them in 2014.

Area of expertise: phospholipidic composition of membranes, sihnaling system, programmed apoptosis.

Publications: over 15 papers.

Marina Vladimirovna Isakina

Marina Vladimirovna Isakina was born in 1989 in Saransk. Entered the Ogarev Mordovia State University in 2006 and graduated from the department of Physics and Chemistry in 2011. Completed her post-graduate studies in 2014. 

Area of expertise: regenerative medicine, pharmacological correction of pathology of peripheral nervous system.

Publications: over 10 papers.

AUXILIARY EDUCATIONAL STUFF

Maria Nikolaevna Grishanova

Maria Nikolaevna Grishanova was born on 22 September 1953 in Cgeberchino village in the Republic of Mordovia, Russia. Graduated from the Department of Biology of the Ogarev Mordovia State University in 1977. Worked as a teaching expert and a senior assistant. Head of the university laboratory of the Chair of Biotechnology, Biochemistry and Bioengineering since 2000. Took a great part in development of the laboratory and creation of workshop on Biophysics. Has been carrying out governmental researches.

Nadezhda Petrovovna Gedoskina

Nadezhda Petrovovna Gedoskina was born on 29 June 1951 in Ardatovo, Russia. Completed an external program of the Department of Chemistry and Biology of the Ogarev Mordovia State University in 1981. From 1977 to 2008 worked at «Biokhimik» industrial plant as a machine operative, laboratory assistant, chief laboratory assistant, microbiologist, chief microbiologist, head of the microbiological unit).

Chief laboratory assistant of the Chair since February, 2009.

Area of expertise: microbic biotechnologies, bacterial exopolysaccharides.

Yulia Aleksandrovna Sutulova

Yulia Aleksandrovna Sutulova was born in Vyatskie polyani, the Kirov region, Russia. Studied at Vyatsko-polyanskaya secondary school from 1991 to 2001. Entered the Department of Biology of the Ogarev Mordovia State University in 2001, graduated from it in 2006. Chief laboratory assistant since 2006, head of university laboratories of the Chair of Biotechnology, Biochemistry and Bioengineering since 2013.

Nina Gerasimovna Savchenko

A laboratory assistant of the Сenter of Biotechnology since 2011.

Natalia Nikolaevna Alemanova

Natalia Nikolaevna Alemanova was born on 1 February 1985 in Otradnoe village in Mordovia, Russia. Entered the Department of Biology of the Ogarev Mordovia State University in 2002, graduated from it in 2007. Chief laboratory assistant of the Chair of Biotechnology, Biochemistry and Bioengineering since 2007.

Irina Yurievna Kotova

Irina Yurievna Kotova was born on 2 August 1964 in Magdeburg, Germany.  Studied at Gvardeiskaya secondary school from 1971 to 1981. Entered the Department of Biology of the Ogarev Mordovia State University in 1982, graduated from it in 1987. Chief laboratory assistant at the Chair of Biotechnology, Bioengineering and Biochemistry since 2011.

Ekaterina Alekseevna Babina

Ekaterina Alekseevna Babina was born on 7 February 1990 in Saransk, Russia. Studied at the secondary school №15 from 1997 to 2007. Entered the Department of Biology of the Ogarev Mordovia State University in 2007, graduated from it in 2012. Chief laboratory assistant of the Chair of Biotechnology, Bioengineering and Biochemistry since 2015.

Nadezhda Evgenievna Nazarova

Laboratory assistant of the Chair of Biotechnology, Bioengineering and Biochemistry since 2013.

Oksana Valerievna Bochkareva

Laboratory assistant of the Chair of Biotechnology, Bioengineering and Biochemistry since 2013.

Tatiana Sergeevna Druzhinkina

Laboratory assistance of the Chair of Biotechnology, Bioengineering and Biochemistry.

Elena Venedictovna Kuznetsova

Laboratory assistant of the Chair of Biotechnology, Bioengineering and Biochemistry since 2012.

Roman Yurievich Kibakov

Laboratory assistant of the Chair of Biotechnology, Bioengineering and Biochemistry since 2014.

POST-GRADUATE STUDENTS OF THE CHAIR OF BIOTECHNOLOGY, BIOENGINEERING AND BIOCHEMISTRY

Nikolai Vasilievich Novokuptsev

Nikolai Vasilievich Novokuptsev was born on 7 February 1990 in Kulikovka village, Mordovia, Russia. Entered the Department of Biology of the Ogarev Mordovia State University in 2007, graduated from it in 2012 with honors. Started his post-graduate studies in 2012. Head of Youth Center for Innovations of the department of Biotechnology and Biology.

Area of expertise: azotobactervinilandi strain D-08, exopolysaccharide levana, environmental safety, biocomposite materials.

Publications: over 5 papers.

Ekaterina Aleksandrovna Levina

Ekaterina Aleksandrovna Levina was born on 6 November 1991 in Saransk. Entered the Ogarev Mordovia State University in 2008 and graduated from it in 2013. Started her post-graduate studies in 2013.

Area of expertise: bioethanol, cellulolytic enzymatic preparations.

Elena Victorovna Kezina

Elena Victorovna Kezina was born on 15 December1990 in Tengushevo village, Mordovia, Russia. Entered the Ogarev Mordovia State University in 2008. Graduated from the Department of Biotechnology and Biology in 2013 and started her post-graduate studies in 2013. 

Area of expertise: composite materials.

Sergey Ivanovich Pinyaev

Sergey Ivanovich Pinyaev was born on 22 September 1990. Entered the Department of Biotechnology and Biology of the Ogarev Mordovia State University in 2008, graduated from it in 2013 and started his post-graduate studies the same year.

Area of expertise: regeneration of damaged peripherical nerves, influence of physiologically active compounds on nerve’s regeneration.

Evgeniy Vladimirovich Tutyaev

Evgeniy Vladimirovich Tutyaev was born on 25 September 1990 in Novaya Aleksamdrovka village, Modovia, Russia. Graduated from the Department of Biology of the Ogarev Mordovia State University in 2012 with honors. Post-graduate student of the Chair of Biochemistry (2012-2014) and of the Chair of Biotechnology, Bioengineering and Biochemistry (2014-present).

Area of expertise: biochemistry and biophysics of photosynthetic processes, CR-spectroscopy of carotinoids. 

Publications: 19 papers, including 3 VAK articles and 1 Web of Science and Scopus article.

Michael Vladimiovich Shankin

Michael Vladimiovich Shankin was born on 29 November 1990 in Staroe Shaigovo village, Mordovia, Saransk. Graduated from the Ogarev Mordovia State University in 2014 and started his post-graduate studies in Biotechnology the same year.

Area of expertise: microbiology, bacterial exopolysaccharides, bacterial cellulose, nanocomposite materials based on bacterial cellulose. 

Publications: 6 papers.

Alena Olegovna Bogatyreva

Alena Olegovna Bogatyreva was born 21 September 1991 in Saransk. Graduated from the OMSU and began her post-graduate studies in «Biotechnology (nanobiotechnology» in 2014.

Area of expertise: microbiology, bacterial exopolysaccharides, bacterial cellulose.

Publications: 8 papers

Nataliya Borisovna Sapunova

Nataliya Borisovna Sapunova was born in Khabarovsk. Entered the department of Biotechnology and Biology of the OMSU in 2010, graduated from it in 2015 with distinction and began her post-graduate studies.

Area of expertise: microbal biotechnologies, bacterial exopolysaccharides, bacterial cellulose.

For the attention of graduates of Russian and foreign universities!

The Department of Biotechnology and Biology of the Ogarev Mordovia State University has the following Master’s programs available:

– 06.04.01 «Biology», Master’s degree in «Biochemistry and molecular biology» (courses duration: 2 years).

– 19.04.01 «Biotechnology» (priority direction of development №1), Master’s degree in « Biotechnology of biocomposite materials» (courses duration: 2 years).

The Department of Biotechnology and Biology of the Ogarev Mordovia State University has the following Master’s programs available:

The Department of Biotechnology and Biology of the Ogarev Mordovia State University has the following Postgraduate Courses available:

– 03.01.02 «Biophysics» (courses duration: 4 years).

– 03.01.04 «Biochemistry » (courses duration: 4 years).

– 03.01.06 «Biotechnology (including bionanotechnologies)» (courses duration: 4 years).

The Department of Biotechnology and Biology of the Ogarev Mordovia State University has the following Bachelor’s programs available:

– 06.03.01 «Biology», Bachelor’s degree in «Biochemistry»

– 19.03.01 «Biotechnology», Bachelor’s degree in «Alimentary Biotechnology», « Biotechnology of medicinal preparations», «Fundamental Biotechnology».

Mode of attendance-intramural (4 years), extramural (5 years), extramural with shortened program (based on specialized secondary vocational education and higher professional education-3.5 years)

The Unified State Exams in Biology, Mathematics and Russian language are used as entrance examinations. When tuition is completed on a shortened program the entrance exams are conducted in the form of an interview on the same subjects.

Tuition is based at the Chair of Biotechnology, Bioengineering and Biochemistry. In 2006 the Center of Biotechnology was opened that later became a base for two now functioning RECs – «Nanobiotechnology» and «DNA-diagnostics». The Center has several laboratories: the Laboratory of Biophysics, of Microbic Biotechnology, of Spectral Analysis, of Physico-chemical methods of analysis, of Cellular and Genetic Engineering, of Chromatographic Analysis and of Sedimentation. They are complete with modern equipment for conducting the researches on molecular-genetic, cellular and organismic level. Research process is constantly improved by implementing of new methods such as: cultivation of objects in bioreactors with programmed controls, microscopy with a system of digital visualization and computer system of analysis, methods of analytic control with modern chromatographic and electrophoretic equipment with electronic data processing, various PCR modifications, DNA sequencing, etc. All of this will allow the Masters and post-graduate students of the Chair to conduct obtaining, researching and applying of bioobjects and their components in various branches of national economy and to work in research teams (through official employment via the scientific wages contract).

Here are the main advantages of completing the Master’s of Post-graduate studies: innovative approach, practical applicability, RECs, qualified academic staff, wide specialization in various industrial spheres (food, processing, pharmaceutical, microbiological, ecological, scientific and research), and a constant demand for the graduates in Russia and abroad.

Dear graduates! The future lies with Natural Sciences and Engineering specialities! Entering our Chair will make you a successful and demanded specialist at the labor-market. We’re looking forward to working with you!

COOPERATION BETWEEN THE CHAIR OF BIOTECHNOLOGY, BIOENGINEERING AND BIOCHEMISTRY AND OTHER RUSSIAN AND INTERNATIONAL INSTITUTIONS

Cooperation in Russia

1. JSC «National Scientific and Research Institute for Biosynthesis of Proteic Substances», 2010, scientific and technical cooperation agreement with the Laboratory of technical biochemistry of the JSC « National Scientific and Research Institute for Biosynthesis of Proteic Substances». Purpose of the agreement: to conduct cooperative researches in priority branches of biotechnology.

2. SUE RM «Teplichnoe», 2010. The agreement for scientific and technical cooperation in sphere of training of highly-qualified specialists, carrying out scientific researches and field tests of products for plants protection with growth-stimulatory and anti-fungal properties.

3. FSBEI HPO «Kazan State Technological University», 2011. Purpose of the agreement is to increase the quality of training of academic staff, to enlarge the area of researches and to promote the universities within the global scientific community.

4. «P. G. Smidovich Mordovian State Nature Reserve», 2011. Cooperation agreement for the increase of academic staff training quality and enlarging the area of researches.

5. RAS Institution «G. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms», 2011. Agreement for conducting of cooperative scientific researches in various spheres of biotechnology and academic staff training. 

6. «Transneft Research Institute for Oil and Oil Products Transportation», 2012. Agreement for information interchange and confidentiality compliance of information. 

7. LLC «Transneft Research Institute for Oil and Oil Products Transportation», 2012. Agreement for increase of efficiency, security and safety of oil transportation.

8. «Saint-Petersburg ITMO University», 2012. Agreement for increase of the quality of training of academic staff, enlarging the area of researches and promoting the universities within the global scientific community.

9. JSC «Biosynthesis», 2012. Agreement for scientific and technical cooperation in sphere of highly-qualified specialist training, conducting of scientific researches, laboratory work and practical training in sphere of biotechnology of medical products. 

10. «National Research University of Electronic Technology», 2012. Agreement for increase of the quality of training of academic staff, enlarging the area of researches and promoting the universities within the global scientific community.

11. FSBI «Timiryazev Institute of Plant Physiology Russian Academy of Sciences», 2012. Agreement for scientific and technical cooperation in sphere of preserving seeds of plants listed in the International Red Book , Red Book of Russia and regional Red Books, for example Red Book of Mordovia, in cryogenic nitrogen. 

12. FSBEI HPO «Togliatti State University», 2013. Agreement for global development of interacademic relations, cooperation in sphere of academic and scientific activities. 

13. LLC «Innovative-technical Center of Mordovia», 2013. Agreement for development of mutually beneficial cooperation in order to train programmer engineer. 

14.  FSBEI HPO «Lomonosov Moscow State University of Fine Chemical Techologies», 2013. Agreement for increase of academic staff training quality, enlarging of the area of scientific researches and promoting the universities within the global scientific community.

15. «Mordovspirt», 2014. Agreement for implementation of practical training, work practice and predegree practice at the enterprises of «Mordovspirt».

16. FSAEI «Lobachevsky University», 2014. Agreement for scientific and research cooperation in the project «Development of technological basis of obtaining of heavy-duty construction materials with polymer matrix, reinforced with nanocrystal cellulose with a high aspectual ratio obtained from high-productive strains and plant raw material».

17. FSBEI HPO «Samara State University», 2014. Agreement for exchange of various scientific and technical production and conducting of the project «Studying of the conditions of obtaining of new products and materials from microbic polysaccharides».

18. FSBEI HPO «Belgorod National Research University». Agreement for increase of quality of high-qualified specialists training, conducting of fundamental, exploratory and applied scientific researches in sphere of trending problems of medicine and pharmaceutics. 

19. JSC «Biokhimik». Agreement for high-qualified specialists training , conducting of researches, laboratory works and work practices in sphere of biotechnology of medical products. 

International cooperation

1. «Babes-Bolyai University», Romania, 2010. Agreement for cooperation activities between the staff of the Chairs of Biology and Geology, Chemistry and  Chemical Engineering and the Chair of Biotechnology and Biology in order to train Higher Education professionals and high-qualified specialists in sphere of Biology, Ecology and Biotechnology.

2. «SP Technical Research Institute of Sweden» and « Innovative-technical Center of Mordovia», 2012.  Agreement in scientific and innovative spheres. 

3. «State University of Novi Pazar», Serbia, 2012. Agreement for a long-term scientific cooperation in spheres of scientific, educational, industrial, social and cultural interest and needs of both countries, in particular in sphere of cell’s biochemistry, biotechnology and ecology. 

4. «Ivane Javakhishvili Tbilisi State University», 2014. Agreement for cooperation in sphere of educational services and conducting of educational and scientific researches.

5. «Baku State University», Azerbaijan, 2014. Agreement for mutual enrichment of scientific, cultural and academic potential of both parties. 

6. «Belarusian State University», 2014. Agreement for increase of quality of education and enlarging of the area of scientific researches. 

7. «Institute of Biophysics and Cell Engineering», Belarus, 2014. Agreement for educational and scientific cooperation, assist the functioning of systems of Higher education, training of high-qualified specialists and Higher Education professionals, constant advanced training and integration of professional education and science. 

STUDY AIDS AND PATENTS OF THE SUB-DEPARTMENT OF BIOTECHNOLOGY, BIOENGINEERING AND BIOCHEMSTRY

1. Patent № 2017594, Russian Federation, MPK5В27N1/02. Method for the wood plastics production / V.D. Cherkasov, V.I. Solomatov, V.G. Inozemtsev, V.P. Selyaev, V.V. Rusakov, V.V. Revin and others; patentee V.I. Solomatov. – №5013874: application for a patent 02.12.1991; date of publication 15.08.1994. 

2. Patent № 2017769, Russian Federation, C08L97/02, C08K3/24, B27N3/02 Adhesive for the wood boards production  / V.D. Cherkasov; V.I. Solomatov; V.G. Inozemtsev; V.P. Selyaev; V.A. Rusakov; V.V. Revin; V.I. Buzulukov; A.I. Merkulov; S.I. Poltavtsev; applicant and patentee: Moscow State University of Railway Engineering (MIIT) – № 5014216/05 : application for a patent 02.12.1991; date of publication15.08.1994

3. Patent № 2017594, Russian Federation, B27N1/02. Method for the wood plastics production / V.D. Cherkasov; V.I. Solomatov; V.G. Inozemtsev; V.P. Selyaev; V.A. Rusakov; V.V. Revin; O.A. Evlanova; M.A. Tahirov; S. Ch. Annaev; applicant and patentee: V.I. Solomatov. – № 5013874/05: application for a patent 02.12.1991; date of publication 15.08.1994

4. Patent № 2026176, Russian Federation, MPK6B27N3/00. Method for the lignin-carbohydrate wood plastics production / V.D. Cherkasov, V.I. Solomatov, V.P. Selyaev, V.V. Rusakov, V.I. Buzulukov, V.V. Revin and others; applicant and patentee; N.P. Ogarev Mordovia State University. –№5022113/05: application for a patent 16.01.1992; date of publication 09.01.1995. 

5. Patent № 2026176, Russian Federation, B27N3/00. Method for the lignin-carbohydrate wood plastics production / V.D. Cherkasov; V.I. Solomatov; V.P. Selyaev; V.A. Rusakov; V.I. Buzulukov; V.V. Revin; V.I. Trohin; G.I. Didenko; applicant and patentee; N.P. Ogarev Mordovia State University. – № 5022113/05: application for a patent 16.01.1992; date of publication 09.01.1995

6. Patent № 2067562, Russian Federation, C04B7/00, C04B7/00, C04B24:00, C04B111:20 Adhesive / V.I. Solomatov, V.D. Cherkasov, S.I. Poltavtsev, V.P. Selyaev, V.A. Rusakov, T.N. Prytkova, V.V. Revin, V.I. Buzulukov; applicant and patentee: Moscow State University of Railway Engineering (MIIT) – № 93025308/33: application for a patent 27.04.1993; date of publication 10.10.1996. 

7. Patent № 2132348, Russian Federation, MPK6C09J105/02. Adhesive composition / V.V. Revin, D.A. Kadimaliev, V.N. Khokhlov; applicant and patentee: N.P. Ogarev Mordovia State University, LLC "Alatyr Paper Factory". – № 97105510 / 04: application for a patent 09.04.1997; date of publication 27.06.1999. 

8. Patent № 2407798 C1, Russian Federation, MPK C12P 7/06. Alcohol production process / V.V. Revin, N.A. Atykyan; applicant and patentee: LLC «Science-Service-S». – № 2009115345/13: application for a patent 22.04.2009; date of publication 22.04.2009

9. Patent № 2133239, Russian Federation, C04B28/02, C04B28/02, C04B24:00, C04B111:20 Method of concrete admixture production / V.I. Solomatov, V.D. Cherkasov, V.V. Revin, V.I. Buzulukov, S.V. Dudynov; applicant and patentee N.P. Ogarev Mordovia State University – № 97115612/03: application for a patent 02.09.1997; date of publication 20.07.1999. 

10. Patent № 2155790, Russian Federation, MPK7C09J189/00. Adhesive composition / V.V. Revin, D.A. Kadimaliev, A.K. Vatolin, V.N. Khokhlov; applicant and patentee: N.P. Ogarev Mordovia State University. – №98119825/04: application for a patent 02.11.1998; date of publication 10. 09. 2000.

11. Patent № 2255077, Russian Federation, MPK A01K 67/033, MPK C05F 3/00. Method of biohumus production / A. Yu. Ivanov, V.V. Revin, A.B. Ruchin; applicant and patentee: N.P. Ogarev Mordovia State University. – № 2003138049/12: application for a patent 29.12.2003; date of publication: 27.06.2005

12. Patent № 2211234, Russian Federation, MPK7C09J105/02. Adhesive composition and its production method / V.V. Revin, A.K. Vatolin, V.M. Groshev; applicant and patentee: V.V. Revin, A.K. Vatolin, V.M. Groshev – № 2001100599/04: application for a patent 09.01.2001; date of publication 27.08.2003. 

13. Patent № 2017594, Russian Federation, MPK723К1/14, А01G1|04, С12N1/14, С12R1:645. Method for the feedstuff production / V.V. Revin, V.A. Atykyan; applicant and patentee: N.P. Ogarev Mordovia State University. – №2001117048/13: application for a patent 18.06.2001; date of publication 20.01.2003. 

14. Patent № 2210495, Russian Federation, MPK7B27N3/04. Method for lignin-carbohydrate plastics production from cotton stem / V.V. Revin, D.A. Kadimaliev, V.V. Shutova; applicant and patentee; N.P. Ogarev Mordovia State University. –№2002103196/13: application for a patent 04.02.2002; date of publication 20.08.2003. 

15. Patent № 2229203, Russian Federation, MPK7A01B79/02, B09C1/00. Phytoremediation  method in soil weeding from heavy metals / V.V. Revin, L.T. Sankayeva, V.I. Kudryashova; applicant and patentee: N.P. Ogarev Mordovia State University. – № 2002126837/12: application for a patent 07.10.2002; date of publication 27.05.2004. 

16. Patent № 2248713, Russian Federation, MPK7А23С19 / 08, А23С19 / 082. Method for the processed cheese production / M.S. Vasyukov, V.V. Revin; applicant and patentee: N.P. Ogarev Mordovia State University. –№2002130874/13: application for a patent 18.11.2002; date of publication 27. 03. 2005. 

17. Patent № 2262275, Russian Federation, MPK7А23L1 / 24, А23L1 / 30. Sour Cream Sauce / M.S. Vasyukov, V.V. Revin, L.V. Vasyukova; applicant and patentee: N.P. Ogarev Mordovia State University. – № 2002132666/13: application for a patent 04.12.2002; date of publication 20.10.2005. 

18. Patent № 2255979, Russian Federation, MPK7C12S3/04, A23K1/12, C12N1/14, B01J19/10C12N1/14, C12R1:645. Method for the lignin bio-conversion of plant raw materials waste / V.V. Revin, D.A. Kadimaliev, N.A. Atykyan; applicant and patentee: N.P. Ogarev Mordovia State University. –№2003112401/13: application for a patent 25.04.2003; date of publication 10.07.2005. 

19. Microorganisms Depositing Certificate, Xanthomonas campestris / V.V. Revin, E.V. Liyaskina, V.M. Groshev: Registration number ВКМ В–2373 D awarded in 5.12.2005. 

20. Patent № 2271198, Russian Federation. Method for the toxic dyspepsia treatment and prophylaxis of newborn calf / R.E. Kiseleva, L.V. Kuzmicheva, R.V. Borchenko; applicant and patentee: Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University: application for a patent 17.02.2005; date of publication 10.03.2006. 

21. Patent № 2286350, Russian Federation. C07K14/765A61K38/38. Method for the veterinary albumin production / R.E. Kiseleva, L.V. Kuzmicheva, R.V. Borchenko; applicant and patentee: Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University. № 2005107397/15: application for a patent 16.03.2005; date of publication 27.10.2006. 

22. Patent № 2331875, Russian Federation MPK2G01N31/22, G01N21 / 78. Method for the photometric diagnosis of ferrum (III) in pure salt solution / V.M. Novopoltseva, K. N. Nishev, D.A. Kadimaliev; applicant and patentee: N.P. Ogarev Mordovia State University: application for a patent 13.06.2006; date of publication 10.12.2007. 

23. Patent №2007106332/04, Russian Federation. Method for the pectin production / N.V. Alba, G.S. Barnashova, L.D. Alba; applicant and patentee: Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University: application for a patent 19.02.2007; date of publication 20.04.2008. 

24. Patent № 2339601, Russian Federation, MPKC05F5/00, A01K67/033. Method for the biohumus production / A.V. Ruchin, V.V. Revin; applicant and patentee: Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University – №2007110011/12: application for a patent 19.03.2007; date of publication 27.11.2008. 

25. Patent № 2343176, Russian Federation, MPK C09J105/00, C09J7/04, C09J199/00. Method for the adhesive composition production / V.V. Revin, T.A. Vedyashkina; applicant and patentee: Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University – № 2007141061/04: application for a patent 06.11.2007; date of publication 10.01.2009. 

26. Patent № 2361659, Russian Federation, МПКB01J20/24. Method for sorbents production / V.V. Revin, S.A. Yamashkin, A.N. Cherentayev; applicant and patentee: V.V. Revin, S.A. Yamashkin, A.N. Cherentayev – № 2008116924 / 15: application for a patent 28. 04. 2008; date of publication 20. 07. 2009. 

27. Patent № 2345957, Russian Federation, МПКC02F3 / 34, C12N1 / 14, C12R1 / 645. Method for biodestruction of phenol / D.A. Kadimaliev, V.V. Revin, A.A. Parshin, O.S. Nadezhina, N.A. Atykyan, A.B. Rubin, K.V. Shaytan; applicant and patentee: N.P. Ogarev Mordovia State University – №2007123842 / 13: application for a patent 25. 06. 2007; date of publication 10. 02. 2010. 

28. Patent № 2399301, Russian Federation. Method for the elevation of pectin gelling power / L.V. Kuzmicheva, R.V. Borchenko, O.S. Novozhilova, E.V.Romanova; applicant and patentee: Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University: application for a patent 11. 01. 2009; date of publication 20. 09. 2010. 

29. Patent № 2404222, Russian Federation, МПКC09J201 / 00, C09J189 / 00 D21H21 / 16, D21H17 / 01. Adhesive composition for paper gluing  / D.A. Kadimaliev, M.I. Mamedov, S.V. Malushkin, E.D. Kadimaliev; applicant and patentee: D.A. Kadimaliev  – № 2009110657 / 04: application for a date 23. 03. 2009; date of publication 20. 11. 2010. 

30. Patent № 2407798, Russian Federation, МПКC12P7 / 06. Alcohol production process / V.V. Revin, N.A. Atykyan; applicant and                                                                                     patentee LLC "Science–Service–S". –№ 2009115345 / 13: application for a patent 22. 04. 2009; date of publication 27. 12. 2010. 

31. Patent № 2558303, Russian Federation, C12P7 / 08. Method for the alcohol production from lignocellulosic materials / O.D. Zaharkin, N.A. Atykyan, V.V. Revin; applicant and patentee: Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University – № 2013144650 / 10. 

32. Patent № 2421967, Russian Federation. Способ получения оболочки для предпосевной обработки семян / V.V. Revin, S.A. Ibragimova; applicant and patentee: LLC "Science-Service-S", Federal State-Financed Academic Institution of Higher Education "N.P. Ogarev Mordovia State University": application for a patent 06.04.2010; date of publication 27.06.2011. 

33. Patent № 2454973, Russian Federation. Method for the non-drug relief of hyperlipidemia / L.V. Kuzmicheva, R.V. Borchenko, E.V. Bystrova, S. I. Shindenkova, Kovalenko S.S.; applicant and patentee: Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University: application for a patent 30.12.2010; date of publication 10.07.2012. 

34. Patent № 2457232, Russian Federation, МПКC09J189/00. RU2404222C1, RU2211234С2, GB2185489А, SU1735466 А1SU1348361 А1. Adhesive composition / D.A. Kadimaliev, V.I. Telyatnik, E.D. Kadimaliev, A.A. Parshin; applicant and patentee: Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University – № 2011124662/05: application for a patent 16.06.2011; date of publication 27.06.2012. 

35. Patent № 2482687, Russian Federation, МПК A22C11/00. Method for the semi-smoked sausage production (variants) L.V. Sergeeva, D.A. Kadimaliev, V.V. Biryukov, S.V. Kozerkina; applicant and patentee: Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University – № 2011124724/13, application for a date 16.06.2011; date of publication 27.12.2012. 

36. Patent for an invention № 2473692, Russian Federation. Method for the biological adhesive production / V.V. Revin, V.V. Shutova; applicant and patentee: Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University, LLC "Science-Service-C": application for a patent 06.07.2011; date of publication 27.01.2013. 

37. Patent for an invention № 2481945, Russian Federation, Method for the biocomposite material production / V.V. Revin, V.V. Shutova, T.I. Ivinkina; applicant and patentee: Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University; application for a patent 17.06.2011, date of publication 20.05.2013. 

38. Patent № 2494747, Russian Federation. Method for non-drug relief of hyperlipemia  / L.V. Kuzmicheva, R.V. Borchenko, E.A. Lopatnikova, N.V. Alba, E.V. Bystrova; applicant and patentee: Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University: application for a patent 27.02.2012; date of publication 10.10.2013. 

39. Patent for an invention № 2506312, Russian Federation Method for alcohol production / N.A. Atykyan, V.V. Revin; applicant and patentee: Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University, LLC "Science-Service S": application for a patent 16.04.2012; date of publication 10.02.2014. 

40. Patent № 2523495, Russian Federation, МПКВ27N3/00. Method for the particleboards production / Yu. K. Liyaskin, V.V. Revin, E.V. Liyaskina; applicant and patentee: Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University – № 2012138847: application for a patent 10.09.2012; date of publication 20.09.2014. 

41. Patent № 2523606, Russian Federation,  C12R1/01, C12P19/04, C12N1/20. Isolate Gluconacetobacter sucrofermentans – bacterial cellulose producer / V.V. Revin, E.V. Liyaskina; applicant and patentee: Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University – № 2013111072: application for a patent 12.03.2013; date of publication 27.05.2014. 

42. Patent № 2523495, Russian Federation, C12R1/01, C12P19/04, C12N1/20. Method for the bacterial cellulose production / V.V. Revin, E.V. Liyaskina, M.I. Nazarkina, N.V. Kireev; applicant and patentee: Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University – № 2013127538: application for a patent 17. 06. 2013; date of publication 22. 10. 2014. 

43. Patent № 254529, Russian Federation 2458077С1, US5919574 A1, EA 200901025 A1, EP738299 A1, CN102805143 A. Method for the biodegradable membrane production / L.N. Zamylina, E.V. Kezina, V.P. Varlamov, O.V. Parchaikina,  I.V. Syusin, D.A. Kadimaliev; applicant and patentee: Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University – № 2013153681/05: application for a patent 03.12.2013; date of publication 27.03.2015. 

44. Patent № 2536973, Russian Federation, C12R1/01, C12P19/04, C12N1/20. Method for the bacterial cellulose production / V.V. Revin, E.V. Liyaskina, M.I. Nazarkina; applicant and patentee Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University – № 2013154403 / 10: application for a patent 06.12.2013; date of publication 27.12.2014. 

45. Patent № 2564567, Russian Federation, С12N1/20, B27N1/02, A61L15/28, A61L15/18. Method for the biocomposite production / E.V. Liyaskina, V.V. Revin; applicant and patentee: Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University – № 2014147770: application for a patent 26.11.2014; date of publication 07.09.2015. 

46. Patent № 2564824, Russian Federation. Biodegradable membrane / D.A. Kadimaliev, O.V. Parchaikina, L.N. Zamylina, E.V. Kezina, B.F. Mamin, V.P. Mishkin, Ya. A. Marisova: applicant and patentee; Federal State-Financed Academic Institution of Higher Education N.P. Ogarev Mordovia State University – № 2014128743: application for a patent 11.07.2014; date of publication 09.11.2015 

47. Patent № 2439540 Russian Federation. Photometric Test Method for erbium (III) in pure salt solution / applicant and patentee Novopoltseva V.M., Osipov А.K., K.N. Nishev, D.A Kadimaliev – № 2010130135/28: application for a patent 19.07.2010; date of publication 10.01.2012 

MOST RELEVANT PUBLICATIONS OF THE ACADEMIC STAFF OF THE CHAIR OF BIOTECHNOLOGY, BIOENGINEERING AND BIOCHEMISTRY IN 2010-2015

1. V. V. Revin, A. A. Lukatkin, S. N. Kalinkina, Y. A. Burova. Influence of biopreparation’s concentration on the growth of phytopathogenic fungi in co-culture. // Materials of the international scientific conference «Biotechnology at the beginning of the 3rd millenium». Saransk, «Mordovia EKSPO» publishing house, 2010.- p.63.

2. Y. E. Dragunova, E. N. Milgunova, V.V. Revin, N. A. Atykyan. Influence of the additional source of nitrogenous nutrition associated with preliminary activated and non-activated yeast on alcohol yield // Materials of the international scientific conference «Biotechnology at the beginning of the 3rd millenium». Saransk, «Mordovia EKSPO» publishing house, 2010.- p.76.

3. V.V. Shutova, V.V. Revin, T. I. Ivinkina, I. V. Fadeev. Usage of distillery stillage for cultivating of lactic-fermentation and propionate bacteria // Biotechnology. 2010. №6, v.3. p. 68-74.

4. D. A. Kadimaliev, O.S. Nadezhina, A.A. Parshin, V.V. Revin, N.A. Atykyan, Change in phospholipid composition and phospholipase activity of the fungus Lentinus tigrinus VKM FF3616D during growth in the presence of phenol and pignocellulosic substrates // Biochemistry 2010.,v.75.№11., p.1342-1351.

5. D. A. Kadimaliev, O.S. Nadezhina, A.A. Parshin, V.V. Revin, N.A. Atykyan, Change in phospholipid composition and phospholipase activity of the fungus Lentinus tigrinus VKM FF3616D during growth in the presence of phenol and pignocellulosic substrates // Biochemistry 2010.,v.75.№11., p.1522-1532.

6. V.V. Shutova, N.A. Atylyan, T.A. Vedyashkina, T.I. Ivinkina. Theoretical and practical basis of production of biocomposite materials by using biological bindings (Monograph) // Saransk: OMSU Publishing house, Saransk, 2010.- 280 p.

7. V. V. Revin, Kadimaliev D. A., Atykyan N. A., Nadezhina O.S., Parshin A.A. The Role of Laccase and Peroxidase of Lentinus (Panus) tigrinusFungus in Biodegradation of High Phenol Concentrations in Liquid Medium // Applied Biochemistry and Microbiology, 2011, Vol. 47, No. 1, pp. 66–71.

8. D. A. Kadimaliev, O.S. Nadezhina, A.A. Parshin, V.V. Revin, N.A. Atykyan, Change in phospholipid composition and phospholipase activity of the fungus Lentinus tigrinus VKM f_3616d during growth in the presence of phenol and pignocellulosic substrates // Biochemistry 2010.,v.75.№11., p.1522-1532.

9. A. S. Lukatkin, D. I. Bashmakov, V. V. Revin, T. E. Krendeleva, T. K. Antal, A. B. Rubin. Ecological evaluation of woody plants in Saransk based on chlorophyll fluorescence // Povolzhskiy ecologic journal, 2011, №1, p.87-92.

10. V. V. Revin, Kadimaliev D.A., Parshin A.A., Atykyan N.A., Rubin A.B., Shaytan K.V. The Role of Laccase and Peroxidase of Lentinus (Panus) tigrinus Fungus in Biodegradation of High Phenol Concentrations in Liquid Medium // Applied Biochemistry and Microbiology, 2011, Vol. 47, No. 1, P. 66–71 

11. V.V. Revin, A.A. Lukatkin. Estimation of grow-promoting effect efficiency of the biopreparation based on Pseudomonas aureofaciens on cucumber plants // Ural Medical Academic Science Bulletin. - 2011.- №4/1 (38).-p.106

12. D. A. Kadimaliev, A. A. Parshin, V.V. Revin, N.A. Atykyan, A. B. Rubin, K. V. Shaitan. Role of laccase and peroxidase of Lentinus tigrinus fungus in biodegradation of high concentration of phenol in fluid media // Practical biochemistry and microbiology. 2011. v. 47, №1, p. 1-6.

13. V. V. Revin, E. G. Kostina. Influence of yeastrel concentration in nutritional medium on the biosynthesis of polysaccharide by Azotobacter vinelandii D-05 // Materials of an International Internet conference «Important problems of biochemistry and bionanotechnology». 10-12 November 2011, Kazan. – p. 84-85

14. Y. E. Dragunova, N. A. Atykyan, V. V. Revin. Combining the processes of hydrolysis and fermentation of nanostrucrured grain raw material // Ural Medical Academic Science Bulletin №4/1 (38), 2011, p.194.

15. D. O. Zakharkin, V.V. Revin, N. A. Atykyan. Studying of the influence of degree of wheat grain grinding on accumulation of sugars in mash // Ural Medical Academic Science Bulletin №4/1 (38), 2011, p.197-198.

16. V.V. Revin, M. A. Romanova, N. A. Atykyan. Studying of biochemical activity of Saccharоmyces cerevisiae yeast of «Angel» and «XII» races in cultivation in mash of high-density // Ural Medical Academic Science Bulletin №4/1 (38), 2011, p. 48

17. T.S. Kolmikova, V.V. Revin, S. A. Ibragimova. Infruence of culture liquid Pseudomonas aureofaciens on the cytokinin activity of seeds and sprouts of tomato // Biologically active materials: fundamental and applied issues of their production and usage. Materials of the scientific conference «Noviy svet», Crimea, the Ukraine, 23-28 May, 2011.-Simferopol, 2011. p. 102-104.

18. E.S. Revina, N.V. Gromova, T.E. Timoshina. Changes in phospholipid composition of the spinal cord in rabbits with allergic encephalomyelitis as an experimental model of multiple sclerosis // Bulletin of Experimental Biology and Medicine. 2011. Т. 152. № 2. С. 224–227.

19. Y. A. Burova, V.V. Revin, S. A. Ibragimova. Usage of polysaccharides in treatment of wheat seeds with biopreparation // Ural Medical Academic Science Bulletin №4/1 (38)

20. V.V. Revin, S.R. Allahverdiyev, E. Kirdar, G. Gunduz, D. Kadimaliyev, V. Filonenko, D.A. Rasulova, Z. L. Abbasova, S.I. Gani-Zade, E.M.  Zevnalova. Effective microorganisms (EM) technology in plants // Technology, 2012, 14(4), P.103-106.

21. V. V. Shutova, V.V. Revin, A. I. Yusipovich, E. Y. Parshina, D. O. Zakharkin. Efficiency of fermentative hydrolysis of polysaccharides of lignocellulosic raw material particles depending on their size // Practical biochemistry and microbiology. 2011. v. 48. №3. P. 1-7.

22. V.V. Revin, D. Kadimaliev, V. Telyatnik, A. Parshin, S. Allahverdi, G. Gunduz, E, Kezina, Nejla Asik. Optimization on of the conditions requiired for chemical and biological modification of the yeast waste from beer manufacturing to produce adhesive compositions. // BioResources, 2012, 7(2), P. 1984-1993.

23. A. A. Devyatkin, V.V. Revin, I. V. Susin. Influence of lipids and their metabolites in nucleus ejection in pigeon’s erythrocites // Biological membranes. 2012. v. 29. №5. P. 1-7.

24. Y. A. Burova, V.V. Revin, S.A. Ibragimova. Pseudomonas aureofaciens’ culture liquid effect on the genesis of wheat seeds and phytopathogenic fungi. // Tula State University Bulletin. Natural sciences. v.3 – Tula: Tula State University Publishing house, 2012. №.10. p. 198-206.

25. Y. A. Burova, V.V. Revin, S.A. Ibragimova. Obtaining bacterial suspension Pseudomonas aureofaciens 2006 in molasses and studying some of its properties. // Orenburg State University Bulletin, 2012. №10. p. 61-65.

26. V.V. Shutova, V.V. Revin, A.I. Yusipovich, E.Y. Parshina, D.O. Zaharkin. Effectiveness of enzymatic polysaccharides hydrolysis in ultradisperse lignocellulosic particles with relation to their size. // Applied Biochemistry and Microbiology. 2012 V. 48, number 3 Р. 312-317.

27. V.V. Shutova, A. I. Yusipovich, V. V. Revin, E. Y. Parshina, D. O. Zakharkin. Effectiveness of enzymatic polysaccharides hydrolysis in ultradisperse lignocellulosic particles with relation to their size. // Applied Biochemistry and Microbiology. 2012 V. 48, number 3 Р. 346-352.

28. Y. E. Dragnova, V. V. Revin, N. A. Atykyan. Role of the degree of grinding of grain raw material and yeast preliminary activation in alcohol yield. // Orenburg State University Bulletin, 2012. №10.

29. V. V. Revin, E. S. Revina, A. A. Devyatkin, N. V. Gromova. Role of lipidsin functioning of excitable biological membranes (Monograph) // Saransk, OMSU Pub., 2012. – 476 p.

30. V. V. Revin, G. V. Maksimov, E. V. Tyutyaev, T. S. Kolmikova. Studying of dispertion and intensity of fluorescence of wheat leaf under temperature influence // Moscow State University Bulletin., v. 16- Biology, Biophysics. 2013. №4.

31. V.V. Revin, G. V. Maksimov, E. V. Tyutyaev, T. S. Kolmykova.  Investigation of Fluorescence Intensity and Distribution of Wheat Leaf on Exposure to Temperature // Moscow University Biological Sciences Bulletin, 2014, Vol. 68, No. 4, pp. 6–9

32. O. V. Proskurina, O. G. Korotkova, V. V. Revin, A. M. Rozhkova, V. Y. Matys, A. V. Koshelev, O. N. Okunev, V. A. Nemashkolev, O. A. Sinitsina, A. P. Sinitsin. Endoglucanase Iy Trichoderma Reesei – new component of biocatalysts based on cellulasic complex of Penicillium Verruculosum fungus for hydrolysis of cellulose-containing biomass // Catalysis in industry. №5, 2013. p. 73-80.

33. A. A. Devyatkin, I. V. Susin, V. V. Revin. Influence of lipids and their metabolites on nucleus ejection’s regulation in pigeon’s erythrocites // Biological membranes. – Moscow, 2013. – v. 30, №1.- p. 52-58.

34. V. V. Shutova, V. V. Revin, T. V. Kudaeva. Studying of the effect of Lentinus (Panus) tigrinus fungi on wood waste used to obtain biocomposite materials // Saratov State University Bulletin. New edition. Chemistry, Biology, Ecology. – 2013. –№4. p.80-85.

35.D. A. Chistyakov, V. V. Revin, I. A. Soberin, A. N. Orekhov, Y. V. Bobryshev Mitochondrial Aging and Age-Related Dysfunction of mitochondria // Hindawi Publishing Corporation BioMed Research International Volume 2014, Article ID 238463, 7 pages

36. I. A. Soberin,  Mitrofanov K. Y, V. V. Revin,  Zhelankin A. V; Sazonova, M.A., Postnov, A.Y., Bobryshev Y. V., Orekhov A.N. Quantitative assessment of heteroplasmy of mitochondrial genome: perspectives in diagnostics and methodological pitfalls // BioMed research international Volume:2014 Pages:292017 DOI:10.1155/2014/292017 Published:2014 (Epub 2014 Apr 10)

37. O. V. Proskurina, V. V. Revin, O. G. Korotkova, A. M. Rozhkova, V. Yu. Matys, A. V. Koshelev, O. N. Okunev, V. A. Nemashkalov. Trichoderma reesei endoglucanase IV: A new component of biocatalysts based on the cellulase complex of the fungus Penicillium verruculosum for hydrolysis of cellulose-containing biomass // Catalysis in Industry January 2014, Volume 6, Issue 1, pp 72-78

38. V. V. Revin, N. A. Atykyan, D. O. Zakharkin, V. V. Shutova, M. Yu. Yazykova. Study of the effect of wood ultrafine particles size on their enzymatic hydrolysis efficiency // Journal of Biotechnology. – 2014. – Vol. 185. – Р.S123 – S124.а

39.S. A. Ibragimova, V. V. Revin, A. Zakharkina. Obtaining of biopreparations for plant protection against phytopathogens // Journal of Biotechnology. – 2014. – Vol. 185. – Р.S67. 

40. E. V. Liaskina, V. V. Revin, M. I. Nasarkina. Bacterial exopolisaccharides production using food industry wastes // Journal of Biotechnology. – 2014. – Vol. 185. – Р.S35. 

41.V. V. Revin, N. A. Atykyan, Y. Dragunova. Development of energy saving fermentation method for bioethanol production using ultradisperse particles of starchy raw materials // Journal of Biotechnology. – 2014. – Vol. 34 – 35. 

42. D. A. Kadimaliev, V. V. Shutova, V. V. Revin, V. V. Telyatnik, E. V. Kezina, and T. V. Kudaeva. Relation between Ligninolytic and Phospholipase Activities in the Fungus Lentinus tigrinus // Microbiology, 2014, Vol. 83, No. 4, pp. 335–343.

43.I. A. Soberin, N. V. Korneev, I. V. Romanov, I. V. Shutikhina, V. V. Revin, G. I. Kuntsevich, E. B. Romanenko, V.A. Myasoedova, V. V. Revin, A.N. Orekhov. The effects of garlic powder tablets in subclinical carotid atherosclerosis // Experimental and Clinical Cardiology Volume 20, Issue 1, 2014, Pages 629-638

44.V. V. Revin, S.M. Filatova, I. V. Syusin, M. Y. Yazykova,· E. S. Revina, N. V. Gromova,· A.A. Devyatkin. Study of correlation between state and composition of lipid phase and change in erythrocytes structure under induction of oxidative processes. // International Journal of Hematology - 2015 . V. 101, N. 5, pp. 487-496. 

45.D. A. Kadimaliev, E. Kezina, V. V. Revin, V. I. Telyatnik, O. V. Parchaykina, I. V. Syusin. Residual Brewer’s Yeast Biomass and Bacterial Cellulose as an Alternative to Toxic Phenol-Formaldehyde Binders in Production of Pressed Materials from Waste Wood // BioResources. – USA., 2015. – V.10, N 1, pp. 1644-1656.

46.M.V. Isakina, V. V. Revin, N.V.Revina. Influence of potassium hyaluronate on the content of lysophospholipids and free fatty acids in damaged somatic nerves of rats // Biology and Medicine – 2015. – V. 7, №2. – P. 1-4.

47.D.A. Chistiakov, I.A. Sobenin, V. V. Revin, A.N. Orekhov, Y. V. Bobryshev. Vascular Endothelium: Functioning in Norm, Changes in Atherosclerosis and Current Dietary Approaches to improve Endothelial/ Function // Mini Rev Med Chem.- 2015. V.15, N. 4. pp. 338-350.

49.V. V. Revin, A.N.Orekhov, I.A. Sobenin, Y. V. Bobryshev. Development of Anti-Atherosclerotic Drugs on the Basis of Natural Products using Cell Model Approach // Oxidative Medicine and Cellular Longevity. – 2015

50.V. V. Revin, N. Gromova, E. Revina, N. A. Mel'nikova, L. Balykova, I. Solomadin, A. Tychkov, N. Revina, O. Gromova, I. Anashkina, and V. Yakushkin. Study of the Structure, Oxygen-Transporting Functions, and Ionic Composition of Erythrocytes at Vascular Diseases // Hindawi Publishing Corporation BioMed Research International Volume 2015. Article ID 973973

51.A. G. Zakharov, M. I. Voronova, V. V. Revin, I. S. Mityuhina, D. A. Isaeva, E. V. Kezina, E. F. Kotina. Nanocrystal cellulose and nanocrystal cellulose-based materials // Microbiology, 2014, v. 83, №4, p. 1-10. Chemical fibers, 2015, №4, p. 58-62.

STUDY AIDS, ACADEMIC CURRICULA AND STANDARDS DEVELOPED BY ACADEMIC STAFF OF THE SUB-DEPARTMENT OF BIOTECHNOLOGY, BIOENGINEERING AND BIOCHEMISTRY

Academic publications

1. Atykyan N.A. Preparation and Master’s thesis defense in Biology. (Study manual). / O.P. Melehova, V.V. Revin, A.S. Lukatkin, N.A. Atykyan - Saransk: N.P. Ogarev Mordovia State University Publ., 2010. – 116 p.

2. Atykyan N.A. Etanol biotechnology. (Study manual) / N.A. Atykyan, V.V. Revin, - Saransk: N.P. Ogarev Mordovia State University Publ., 2010. – 104 p.

3. Kostina E.G. Human and animal physiology and biophysics laboratory course. (Study manual). / Е.G. Kostina, V.V. Revin, E.S. Revina - Saransk: N.P. Ogarev Mordovia State University Publ., 2010. – 68 p.

4. Lyaskina E.V. Biotechnology of bacterial exopolysaccharide. (Study manual). / Е.V. Lyaskina, V.M. Groshev, V.V. Revin, Yu.K. Liyaskin - Saransk: N.P. Ogarev Mordovia State University Publ., 2010. – 120 p.

5. Kuzmicheva L. V. Biochemistry: short course / L. V. Kuzmicheva, R. V. Borchenko, O. S. Novozhilova - Saransk: Printery LLC «Beauty Print» 2010. – 154 p.

6. Melnikova N.A., Lapshina M.V., Gromova N.V. Construction and function of visceral systems of human organism (with age features). Saransk: M.E. Evseviev Mordovia State University, 2010. – 92 p., author's part – 30,7 p.

7. Revina E.S., Kuzmicheva L.V., Bystrova E.V. Immunology laboratory course: academic manual: – 2010. – Electronic textbook on CD (registration certificate № 21020 from 25.12.10)

8. Kuzmicheva L.V. Biochemical methods in patalogical body state / L.V. Kuzmicheva, N.V. Alba, O.S. Novozhilova, E.V. Bystrova, R.V. Borchenko Saransk: Printary «Ruzaevka publishing house», 2011. – 168 p.

9. N.A. Atykyan Fundamental biotechnology (Course book) / N.A. Atykyan, V.N. Vodyakov, V.V. Revin, Е.V. Liyaskina. – Saransk: N.P. Ogarev Mordovia State University Publ., 2012. – 476 p.

10. Revina E.S. Lipids role in functioning of excitable biological membranes. (Monography) / E.S. Revina, А.А. Devyatkin, V.V. Revin, N.V. Gromova - Saransk: N.P. Ogarev Mordovia State University Publ., 2012. – 476 p.

11. Kuzmicheva L.V., Borchenko R.V., Novozhilova О.S. Biological chemistry (short course). Saransk: N.P. Ogarev Mordovia State University Publ., 2012. – 173 p.

12. Gromova N.V., Revina E.S. Human biology (short course). Saransk: M.E. Evseviev Mordovia State University, 2012. – 144 p.

13. Gromova N.V. Human biology: academic complex of disciplines [electronic resource] // N.V. Gromova, E.S. Revina. – Saransk: N.P. Ogarev Mordovia State University, 2013.– 215 p. – № official registration number - 0321204503

14. Kuzmicheva L.V.  Biochemistry and molecular biology: academic complex of disciplines [electronic resource] // L.V. Kuzmicheva, R.V. Borchenko, О.S. Novozhilova. – Saransk: N.P. Ogarev Mordovia State University, 2013. – 213. – № official registration number – 0321300890

15. Devyatkin A.A. Lipids: Outflow and analysis methods. (Study manual) / V.V. Revin, А.А. Devyatkin - Saransk: N.P. Ogarev Mordovia State University Publ., 2014. – 108 p.

16. Liyaskina Е.V. Bacterial cellulose and nanocomposite materials preparation. (Monography) / Е.V. Liyaskina, В.В. Revin, N.A. Pestov - Saransk: N.P. Ogarev Mordovia State University Publ., 2014. – 128 p.

17. Liyaskina Е.V. Laboratory course on the Biotechnology basis / Е.V. Liyaskina, S.A. Ibragimova, N.A. Atykyan Saransk: N.P. Ogarev Mordovia State University Publ., 2014. – 64p.

18. Shubina О.S. Animal and Human morphology laboratory researches (academic manual) / О.S. Shubina, N.А. Melikova, М.V. Lapshina // M.E. Evseviev Mordovia State University – Saransk, 2014. – 115 p.

19. Атыкян Н.А. General biotechnology. (Course book) / Н.А. Атыкян., В.Н. Vodyakov, Е.V. Liyaskina, D.A. Kadimaliev, V.V. Shutova, V.V. Revin.- Saransk: N.P. Ogarev Mordovia State University Publ., 2015. – 64p.

Academic curricula and standards

1. Within the range of educational services expansion by PDF (Priority Development Fields) of University in 2011 prepared in 2012 was licensed its own educational standard majoring in Biotechnology (Bachelor's degree).

2. The main vocational education programme in Master’s degree was developed for «Fundamental biotechnology», «Alimental biotechnology», «Biotechnology of medicinal preparations» based on educational standards 19.04.01 Biotechnology (Master’s degree programme).

3. The main vocational education programme in Master’s degree was developed for «Fundamental biotechnology», «Biotechnology of biocomposite materials», «Bioenergy», «Biotechnology of medicinal preparations» based on educational standards 19.04.01 Biotechnology (Master’s degree programme).